R
R. C. Sprong
Researcher at Utrecht University
Publications - 4
Citations - 207
R. C. Sprong is an academic researcher from Utrecht University. The author has contributed to research in topics: Oxidative stress & Acetylcysteine. The author has an hindex of 3, co-authored 4 publications receiving 201 citations.
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Journal ArticleDOI
Low-dose N-Acetylcysteine Protects Rats against Endotoxin-mediated Oxidative Stress, But High-dose Increases Mortality
R. C. Sprong,A. M. L. Winkelhuyzen-Janssen,C. J. M. Aarsman,J. F. L. M. Van Oirschot,T. van der Bruggen,B. S. Van Asbeck +5 more
TL;DR: It is concluded that low-dose NAC protects against LPS toxicity by scavenging H2O2, while higher doses may have the opposite effect.
Journal ArticleDOI
Hydrogen peroxide modulation of the superoxide anion production by stimulated neutrophils.
TL;DR: The balance of reactive oxygen species (ROS) produced by neutrophils in the state of sepsis may thus be autoregulated by negative feedback phenomena of locally produced H202.