Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.

Chemistries that Facilitate Nanotechnology Kim E. Sapsford,† W. Russ Algar, Lorenzo Berti, Kelly Boeneman Gemmill,‡ Brendan J. Casey,† Eunkeu Oh, Michael H. Stewart, and Igor L. Medintz*,‡ †Division of Biology, Department of Chemistry and Materials Science, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, United States ‡Center for Bio/Molecular Science and Engineering Code 6900 and Division of Optical Sciences Code 5611, U.S. Naval Research Laboratory, Washington, D.C. 20375, United States College of Science, George Mason University, 4400 University Drive, Fairfax, Virginia 22030, United States Department of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, California 95817, United States Sotera Defense Solutions, Crofton, Maryland 21114, United States

Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology.

http://if-pan.krakow.pl/pjp/pdf/2012/5_1020.pdf

Nanoparticles as drug delivery systems

Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles.

In recent years, various nanotechnology platforms in the area of medical biology, including both diagnostics and therapy, have gained remarkable attention. Moreover, research and development of engineered multifunctional nanoparticles as pharmaceutical drug carriers have spurred exponential growth in applications to medicine in the last decade. Design principles of these nanoparticles, including nano-emulsions, dendrimers, nano-gold, liposomes, drug-carrier conjugates, antibody-drug complexes, and magnetic nanoparticles, are primarily based on unique assemblies of synthetic, natural, or biological components, including but not limited to synthetic polymers, metal ions, oils, and lipids as their building blocks. However, the potential success of these particles in the clinic relies on consideration of important parameters such as nanoparticle fabrication strategies, their physical properties, drug loading efficiencies, drug release potential, and, most importantly, minimum toxicity of the carrier itself. Among these, lipid-based nanoparticles bear the advantage of being the least toxic for in vivo applications, and significant progress has been made in the area of DNA/RNA and drug delivery using lipid-based nanoassemblies. In this review, we will primarily focus on the recent advances and updates on lipid-based nanoparticles for their projected applications in drug delivery. We begin with a review of current activities in the field of liposomes (the so-called honorary nanoparticles), and challenging issues of targeting and triggering will be discussed in detail. We will further describe nanoparticles derived from a novel class of amphipathic lipids called bolaamphiphiles with unique lipid assembly features that have been recently examined as drug/DNA delivery vehicles. Finally, an overview of an emerging novel class of particles (based on lipid components other than phospholipids), solid lipid nanoparticles and nanostructured lipid carriers will be presented. We conclude with a few examples of clinically successful formulations of currently available lipid-based nanoparticles.

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Lipid-based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic

Nanostructured lipid carriers (NLC) in cosmetic dermal products

Nanostructured lipid carrier : A delivery system with protective functions

Nanostructured lipid carriers (NLC) were developed as the next innovative carrier generation after the liposomes possessing improved properties (1, 2). The first two first two cosmetic NLC products were launched in Europe by Dr. Rimpler GmbH/ Germany in October 2005 (Nanorepair), a development recognized by the European BSB innovatio award 2006 in Germany. Amore Pacific, the largest South Korean cosmetic company, launched the first three NLC products for Asia in Seoul on 1st of September 2006 (Super Vital, line 10PE). The article summarizes the special featuers of NLC and discusses the SOPI concept achieved by NLC techology.

R.-D Petersen

Papers

Nanostructured lipid carriers (NLC) in cosmetic dermal products

Nanostructured lipid carrier : A delivery system with protective functions

Nano Lipid Carriers (NLC): The new cosmetic carrier génération