R
R. Lesley
Researcher at Salk Institute for Biological Studies
Publications - 3
Citations - 2446
R. Lesley is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Toxicity & Cytotoxic T cell. The author has an hindex of 2, co-authored 3 publications receiving 2403 citations.
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Hydrogen peroxide mediates amyloid beta protein toxicity.
TL;DR: The cytotoxic action of A beta on neurons results from free radical damage to susceptible cells, suggesting that A beta activates a member of this class of enzymes.
Journal ArticleDOI
Amyloid peptides are toxic via a common oxidative mechanism
TL;DR: It is shown here that the protein components of other human amyloidoses, including amylin, calcitonin, and atrial natriuretic peptide, are all toxic to clonal and primary cells.
Amyloidpeptides aretoxicviaacommonoxidative mechanism
TL;DR: Experiments with synthetic peptides suggest that theamphiphilic nature of thepeptides gen- erated by their3-sheet conformation rather than their 3-structure rather than the alternative thatamyloid toxicity isexclusively mediated via specific cell surface receptors, which tendtorule out the alternative of commonmechanism forcellular toxicity.