R
R. Marwood
Researcher at Merck & Co.
Publications - 12
Citations - 1195
R. Marwood is an academic researcher from Merck & Co.. The author has contributed to research in topics: Dopamine receptor & Dopamine. The author has an hindex of 11, co-authored 12 publications receiving 1159 citations.
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Journal ArticleDOI
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
Janusz Jozef Kulagowski,Howard B. Broughton,Neil Roy Curtis,Ian M. Mawer,Mark Peter Ridgill,R. Baker,F. Emms,Stephen B. Freedman,R. Marwood,Shil Patel,C I Ragan,Paul D. Leeson +11 more
Journal Article
Expression and pharmacological characterization of the human D3 dopamine receptor.
Stephen B. Freedman,Shil Patel,R. Marwood,F. Emms,Guy R. Seabrook,M.R. Knowles,G. Mcallister +6 more
TL;DR: The finding that a wide range of structurally diverse human dopamine D2 (hD2) receptor agonists have an apparent hD3 selectivity may imply that the hD 3 receptor exists predominantly in a high affinity state.
Journal Article
Biological Profile of L-745,870, a Selective Antagonist with High Affinity for the Dopamine D4 Receptor
Shil Patel,Stephen B. Freedman,K. L. Chapman,F. Emms,A. E. Fletcher,M.R. Knowles,R. Marwood,G. Mcallister,J Myers,N. Curtis,Janusz Jozef Kulagowski,Paul D. Leeson,M. Ridgill,Michael I. Graham,S. Matheson,Denise Rathbone,Alan P. Watt,Linda J. Bristow,N. M. J. Rupniak,E. Baskin,Joseph J. Lynch,C I Ragan +21 more
TL;DR: Results show that dopamine D4 receptor antagonism in the brain does not result in the same neurochemical consequences (increased dopamine metabolism or hyperprolactinemia) observed with typical neuroleptics.
Journal ArticleDOI
3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists.
Michael Rowley,David James Hallett,Simon Charles Goodacre,Christopher Moyes,James Michael Crawforth,Timothy Jason Sparey,Shil Patel,R. Marwood,Steve Thomas,Laure Hitzel,Desmond O'Connor,Nicola Szeto,Castro Jl,Peter H. Hutson,Angus Murray Macleod +14 more
TL;DR: It was found that with the basic nitrogen at the 3-position of the piperidine it was not necessary to further substitute the p Piperidine in order to obtain good binding at h5-HT(2A) receptors.