S
Shil Patel
Researcher at United States Military Academy
Publications - 51
Citations - 3140
Shil Patel is an academic researcher from United States Military Academy. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 30, co-authored 51 publications receiving 3017 citations. Previous affiliations of Shil Patel include Merck Sharp & Dohme Federal Credit Union & Merck & Co..
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Journal ArticleDOI
[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
H. Donald Burns,Koen Van Laere,Sandra M. Sanabria-Bohórquez,Terence G. Hamill,Guy Bormans,Wai-Si Eng,Ray E Gibson,Christine E. Ryan,Brett Connolly,Shil Patel,Stephen Krause,Amy Vanko,Anne Van Hecken,Patrick Dupont,Inge De Lepeleire,Paul Rothenberg,S. Aubrey Stoch,Josee Cote,William K. Hagmann,James P. Jewell,Linus S. Lin,Ping Liu,Mark T. Goulet,Keith Gottesdiener,John A. Wagner,Jan de Hoon,Luc Mortelmans,Tung M. Fong,Richard Hargreaves +28 more
TL;DR: Autoradiographic studies in rhesus monkey brain showed that [18F]MK-9470 binding is aligned with the reported distribution of CB1 receptors with high specific binding in the cerebral cortex, cerebellum, caudate/putamen, globus pallidus, substantia nigra, and hippocampus, and PET imaging studies in human research subject demonstrated behavior very similar to that seen in monkeys.
Journal ArticleDOI
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
Janusz Jozef Kulagowski,Howard B. Broughton,Neil Roy Curtis,Ian M. Mawer,Mark Peter Ridgill,R. Baker,F. Emms,Stephen B. Freedman,R. Marwood,Shil Patel,C I Ragan,Paul D. Leeson +11 more
Journal Article
Expression and pharmacological characterization of the human D3 dopamine receptor.
Stephen B. Freedman,Shil Patel,R. Marwood,F. Emms,Guy R. Seabrook,M.R. Knowles,G. Mcallister +6 more
TL;DR: The finding that a wide range of structurally diverse human dopamine D2 (hD2) receptor agonists have an apparent hD3 selectivity may imply that the hD 3 receptor exists predominantly in a high affinity state.
Journal ArticleDOI
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.
Martin R. Guscott,Linda J. Bristow,K. L. Hadingham,Thomas W. Rosahl,Margaret S. Beer,Josephine A. Stanton,Frances A. Bromidge,Andrew Pate Owens,Ian Thomas Huscroft,J Myers,Nadia Melanie Rupniak,Shil Patel,Paul J. Whiting,Peter H. Hutson,Kevin C. F. Fone,Stephany M. Biello,Janusz Jozef Kulagowski,George McAllister +17 more
TL;DR: These pharmacological and genetic knockout studies provide the first direct evidence that 5-HT7 receptor antagonists should be investigated for efficacy in the treatment of depression.
Journal Article
Biological Profile of L-745,870, a Selective Antagonist with High Affinity for the Dopamine D4 Receptor
Shil Patel,Stephen B. Freedman,K. L. Chapman,F. Emms,A. E. Fletcher,M.R. Knowles,R. Marwood,G. Mcallister,J Myers,N. Curtis,Janusz Jozef Kulagowski,Paul D. Leeson,M. Ridgill,Michael I. Graham,S. Matheson,Denise Rathbone,Alan P. Watt,Linda J. Bristow,N. M. J. Rupniak,E. Baskin,Joseph J. Lynch,C I Ragan +21 more
TL;DR: Results show that dopamine D4 receptor antagonism in the brain does not result in the same neurochemical consequences (increased dopamine metabolism or hyperprolactinemia) observed with typical neuroleptics.