R
R. Ofman
Researcher at Boston Children's Hospital
Publications - 2
Citations - 86
R. Ofman is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Peroxisome & Adrenoleukodystrophy. The author has an hindex of 2, co-authored 2 publications receiving 81 citations. Previous affiliations of R. Ofman include University of Amsterdam.
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Characterization of the human {omega}-oxidation pathway for {omega}-hydroxy-very-long-chain fatty acids
TL;DR: Enzyme kinetic studies show that oxidation of ω‐hydroxy‐VLCFAs occurs predominantly via the NAD+‐dependent route, and overall, the data demonstrate that in humans all enzymes are present for the com plete conversion of V LCFAs to their corresponding very‐long‐chain dicarboxylic acids.
Journal ArticleDOI
Cholesterol-deprivation increases mono-unsaturated very long-chain fatty acids in skin fibroblasts from patients with X-linked adrenoleukodystrophy.
Marc Engelen,R. Ofman,R. Ofman,P.A.W. Mooijer,P.A.W. Mooijer,B. T. Poll-The,B. T. Poll-The,Ronald J.A. Wanders,Ronald J.A. Wanders,Stephan Kemp,Stephan Kemp +10 more
TL;DR: It is concluded that cholesterol-deprivation reduces saturated V LCFA, but increases mono-unsaturated VLCFA.