R. R. Strauss

TL;DR: Increased activity of this enzyme is an early event involved in the phagocytosis-associated increase in this metabolic pathway, it can be postulate.

TL;DR: The anti-inflammatory drug phenylbutazone has been found to inhibit both engulfment and intracellular killing of E. coli by guinea pig peritoneal polymorphonuclear (PMN) leukocytes and it is suggested that H( 2)O(2) activates lysosomes and subsequently complexes with the lysOSomal enzyme, myeloperoxidase, which is a potent bactericidal agent in the phagocyte.

TL;DR: It appears that myeloperoxidase (MPO) can not only decarboxylate free and bound amino acids, yielding aldehydes, but also it can actively participate in oxidative peptide cleavage, which may play a critical role in the microbicidal action of the leukocyte.

TL;DR: Homogenization and differential centrifugation of guinea pig peritoneal polymorphonuclear leukocytes indicate that the whole homogenate and its fractions from phagocytizing cells have significantly higher MPO and NADPH oxidase activities, when compared to the corresponding fractions from the resting cells.

TL;DR: It is likely that in vivo under most conditions chloride is the functional halide and that generation of aldehydes is the mechanism responsible for the antimicrobial activity of the MPO-H(2)O(2)-chloride system.