Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations.

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The challenge of mapping the human connectome based on diffusion tractography

A review of 3D/2D registration methods for image-guided interventions

Segmentation of anatomical structures in chest radiographs using supervised methods: a comparative study on a public database.

The impressive development of medical imaging technology during the last decades provided physicians with an increasing amount of patient specific anatomical and functional data. In addition, the increasing use of non-ionizing real-time imaging, in particular ultrasound and optical imaging, during surgical procedures created the need for design and development of new visualization and display technology allowing physicians to take full advantage of rich sources of heterogeneous preoperative and intraoperative data. During 90's, medical augmented reality was proposed as a paradigm bringing new visualization and interaction solutions into perspective. This paper not only reviews the related literature but also establishes the relationship between subsets of this body of work in medical augmented reality. It finally discusses the remaining challenges for this young and active multidisciplinary research community.

Advanced Medical Displays: A Literature Review of Augmented Reality

https://shura.shu.ac.uk/7180/1/Rodriggues_%2D_optical_techniques_%2D_Review_MIA_revision_v9.pdf

Optical techniques for 3D surface reconstruction in computer-assisted laparoscopic surgery.

/pdf/validation-of-medical-image-processing-in-image-guided-552liq5t00.pdf

R. Shahidl

Papers

Validation of medical image processing in image-guided therapy