R
R.T. Bossi
Publications - 1
Citations - 149
R.T. Bossi is an academic researcher. The author has contributed to research in topics: Receptor tyrosine kinase & Anaplastic lymphoma kinase. The author has an hindex of 1, co-authored 1 publications receiving 139 citations.
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Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors.
R.T. Bossi,M.B. Saccardo,Elena Ardini,Maria Menichincheri,Luisa Rusconi,Paola Magnaghi,Paolo Orsini,N. Avanzi,A.L. Borgia,M. Nesi,T. Bandiera,Gianpaolo Fogliatto,J.A. Bertrand +12 more
TL;DR: Analysis of the crystal structures of the unphosphorylated human ALK kinase domain in complex with the ATP competitive ligands PHA-E429 and NVP-TAE684 provides valuable information concerning the specific characteristics of the ALK active site as well as giving indications about how to obtain selective ALK inhibitors.