R
R. Thomas Jagoe
Researcher at Jewish General Hospital
Publications - 23
Citations - 5854
R. Thomas Jagoe is an academic researcher from Jewish General Hospital. The author has contributed to research in topics: Muscle atrophy & Skeletal muscle. The author has an hindex of 16, co-authored 23 publications receiving 5061 citations. Previous affiliations of R. Thomas Jagoe include Freeman Hospital & Harvard University.
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Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
TL;DR: Atrogin-1 is one of the few examples of an F-box protein or Ub-protein ligase (E3) expressed in a tissue-specific manner and appears to be a critical component in the enhanced proteolysis leading to muscle atrophy in diverse diseases.
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Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Stewart H. Lecker,R. Thomas Jagoe,Alexander Gilbert,Marcelo Gomes,Vickie E. Baracos,James L. Bailey,S. Russ Price,William E. Mitch,Alfred L. Goldberg +8 more
TL;DR: Different types of skeletal muscle atrophy share a common transcriptional program that is activated in many systemic diseases including diabetes, cancer, and renal failure, according to cDNA microarrays.
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Editorial: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?
TL;DR: RTJ receives salary support from the Peter Brojde Lung Cancer Centre and the Backler Foundation, Jewish General Hospital Foundation.
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Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases
Jennifer M. Sacheck,Jon Philippe K. Hyatt,Anna Raffaello,R. Thomas Jagoe,Roland R. Roy,V. Reggie Edgerton,Stewart H. Lecker,Alfred L. Goldberg +7 more
TL;DR: The atrophy associated with systemic catabolic states and following disuse involves similar transcriptional adaptations; and disuse atrophy proceeds through multiple phases corresponding to rapidly atrophying and atrophied muscles that involve distinct transcriptional patterns.
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Diagnostic Criteria for the Classification of Cancer-Associated Weight Loss
Lisa Martin,Pierre Senesse,Ioannis Gioulbasanis,Sami Antoun,Federico Bozzetti,Chris Deans,Florian Strasser,Lene Thoresen,R. Thomas Jagoe,Martin Chasen,Kent Lundholm,Ingvar Bosaeus,K.C.H. Fearon,Vickie E. Baracos +13 more
TL;DR: A robust grading system incorporating the independent prognostic significance of both BMI and %WL was developed and was observed within specific cancers, stages, ages, and performance status and in an independent validation sample.