S
S. Russ Price
Researcher at East Carolina University
Publications - 68
Citations - 7852
S. Russ Price is an academic researcher from East Carolina University. The author has contributed to research in topics: Protein degradation & Muscle atrophy. The author has an hindex of 35, co-authored 66 publications receiving 7135 citations. Previous affiliations of S. Russ Price include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Ulf Landmesser,Sergey Dikalov,S. Russ Price,Louise McCann,Tohru Fukai,Steven M. Holland,William E. Mitch,David G. Harrison +7 more
TL;DR: Evidence is obtained that hypertension produces a cascade involving production of ROSs from the NADPH oxidase leading to oxidation of tetrahydrobiopterin and uncoupling of endothelial NO synthase (eNOS), which decreases NO production and increases ROS production from eNOS.
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Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Stewart H. Lecker,R. Thomas Jagoe,Alexander Gilbert,Marcelo Gomes,Vickie E. Baracos,James L. Bailey,S. Russ Price,William E. Mitch,Alfred L. Goldberg +8 more
TL;DR: Different types of skeletal muscle atrophy share a common transcriptional program that is activated in many systemic diseases including diabetes, cancer, and renal failure, according to cDNA microarrays.
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Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions
Jie Du,Xiaonan H. Wang,Christiane Miereles,James L. Bailey,Richard Debigare,Bin Zheng,S. Russ Price,William E. Mitch +7 more
TL;DR: It is found that recombinant caspase-3 cleaves actomyosin, producing a characteristic, approximately 14-kDa actin fragment and other proteins that are degraded by the Ub-P'some system.
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Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)
Juan Jesus Carrero,Peter Stenvinkel,Lilian Cuppari,T. Alp Ikizler,Kamyar Kalantar-Zadeh,George A. Kaysen,William E. Mitch,S. Russ Price,S. Russ Price,Christoph Wanner,Angela Yee-Moon Wang,Pieter ter Wee,Harold A. Franch,Harold A. Franch +13 more
TL;DR: This consensus statement of current knowledge on the etiology of PEW syndrome in CKD is provided to increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of Pew.
Journal ArticleDOI
Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting
William E. Mitch,James L. Bailey,Xiaonan H. Wang,Claudine Jurkovitz,David Newby,S. Russ Price +5 more
TL;DR: Acidity is not necessary for these responses, but glucocorticoids and a low insulin level in tandem activate the ubiquitin-proteasome proteolytic system, and this system is stimulated in conditions causing muscle atrophy.