R
Rachel A. Saltness
Researcher at Mayo Clinic
Publications - 1
Citations - 1882
Rachel A. Saltness is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Transgene & Senolytic. The author has an hindex of 1, co-authored 1 publications receiving 1373 citations.
Papers
More filters
Journal ArticleDOI
Naturally occurring p16 Ink4a -positive cells shorten healthy lifespan
Darren J. Baker,Bennett G. Childs,Matej Durik,Melinde Wijers,Cynthia J. Sieben,Jian Zhong,Rachel A. Saltness,Karthik B. Jeganathan,Grace C Verzosa,Abdulmohammad Pezeshki,Khashayarsha Khazaie,Jordan D. Miller,Jan M. van Deursen +12 more
TL;DR: It is shown that compared to vehicle alone, AP20187 treatment extended median lifespan in both male and female mice of two distinct genetic backgrounds and the clearance of p16Ink4a-positive cells delayed tumorigenesis and attenuated age-related deterioration of several organs without apparent side effects.