M
Melinde Wijers
Researcher at University Medical Center Groningen
Publications - 9
Citations - 2272
Melinde Wijers is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: LDL receptor & LRP1. The author has an hindex of 6, co-authored 8 publications receiving 1626 citations. Previous affiliations of Melinde Wijers include Mayo Clinic & University of Groningen.
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Journal ArticleDOI
Naturally occurring p16 Ink4a -positive cells shorten healthy lifespan
Darren J. Baker,Bennett G. Childs,Matej Durik,Melinde Wijers,Cynthia J. Sieben,Jian Zhong,Rachel A. Saltness,Karthik B. Jeganathan,Grace C Verzosa,Abdulmohammad Pezeshki,Khashayarsha Khazaie,Jordan D. Miller,Jan M. van Deursen +12 more
TL;DR: It is shown that compared to vehicle alone, AP20187 treatment extended median lifespan in both male and female mice of two distinct genetic backgrounds and the clearance of p16Ink4a-positive cells delayed tumorigenesis and attenuated age-related deterioration of several organs without apparent side effects.
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CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
Paulina Bartuzi,Daniel D. Billadeau,Robert P. Favier,Shunxing Rong,Daphne Dekker,Alina Fedoseienko,Hille Fieten,Melinde Wijers,Johannes H.M. Levels,Nicolette C. A. Huijkman,Niels J. Kloosterhuis,Henk F. van der Molen,Gemma Brufau,Albert K. Groen,Alison M. Elliott,Jan Albert Kuivenhoven,Barbara Plecko,Barbara Plecko,Gernot Grangl,Julie McGaughran,Jay D. Horton,Ezra Burstein,Marten H. Hofker,Bart van de Sluis +23 more
TL;DR: It is found that patients with X-linked intellectual disability caused by mutations in CCDC22 are hypercholesterolaemic, and that COMMD1-deficient dogs and liver-specific Commd1 knockout mice have elevated plasma LDL cholesterol levels.
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The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking
Alina Fedoseienko,Melinde Wijers,Justina C. Wolters,Daphne Dekker,Marieke Smit,Nicolette C. A. Huijkman,Niels J. Kloosterhuis,Helene Klug,Aloys Schepers,Ko Willems van Dijk,Johannes H.M. Levels,Daniel D. Billadeau,Marten H. Hofker,Jan M. van Deursen,Marit Westerterp,Ezra Burstein,Jan Albert Kuivenhoven,Bart van de Sluis +17 more
TL;DR: A strong interrelationship between COMMD proteins and the core of the CCC complex in endosomal LDLR trafficking is demonstrated and all other COMMDs and CCC components may be potential targets for modulating plasma lipid levels in humans.
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News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1
TL;DR: Comprehensive studies into the molecular regulation of LDLR and LRP1 trafficking have advanced the fundamental understanding of cholesterol homeostasis, and these insights may lead to novel therapeutic strategies for atherosclerosis, hyperlipidemia and insulin resistance in the future.
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The life cycle of the low-density lipoprotein receptor : insights from cellular and in-vivo studies
TL;DR: It is important to learn more about the LDLR trafficking pathway in order to be able to treat and diagnose individuals with hypercholesterolemia in the future, as the fundamental knowledge about the mechanisms regulating this pathway is still incomplete.