R
Rachel Ruckdeschel Smith
Researcher at Cedars-Sinai Medical Center
Publications - 31
Citations - 5033
Rachel Ruckdeschel Smith is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Stem cell & Transplantation. The author has an hindex of 19, co-authored 30 publications receiving 4688 citations.
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Journal ArticleDOI
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
Raj Makkar,Rachel Ruckdeschel Smith,Ke Cheng,Konstantinos Malliaras,Louise Thomson,Daniel S. Berman,Lawrence S.C. Czer,Linda Marbán,Adam Mendizabal,Peter V. Johnston,Stuart D. Russell,Karl H. Schuleri,Albert C. Lardo,Gary Gerstenblith,Eduardo Marbán +14 more
TL;DR: In this paper, Cardiosphere-derived cells (CDCs) were used to reduce scarring after myocardial infarction, increase viable myocardium, and boost cardiac function in preclinical models.
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Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice
Isotta Chimenti,Rachel Ruckdeschel Smith,Tao-Sheng Li,Gary Gerstenblith,Elisa Messina,Alessandro Giacomello,Eduardo Marbán +6 more
TL;DR: Together with their spontaneous commitment to cardiac and angiogenic differentiation, transplanted CDCs serve as “role models,” recruiting endogenous regeneration and improving tissue resistance to ischemic stress.
Journal ArticleDOI
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells.
Tao-Sheng Li,Ke Cheng,Konstantinos Malliaras,Rachel Ruckdeschel Smith,Yiqiang Zhang,Baiming Sun,Noriko Matsushita,Agnieszka Blusztajn,John Terrovitis,Hideo Kusuoka,Linda Marbán,Eduardo Marbán +11 more
TL;DR: CDCs exhibited a balanced profile of paracrine factor production and, among various comparator cell types/subpopulations, provided the greatest functional benefit in experimental myocardial infarction.
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Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction).
Konstantinos Malliaras,Raj Makkar,Rachel Ruckdeschel Smith,Ke Cheng,Edwin Wu,Robert O. Bonow,Linda Marbán,Adam Mendizabal,Eugenio Cingolani,Peter V. Johnston,Gary Gerstenblith,Karl H. Schuleri,Albert C. Lardo,Eduardo Marbán +13 more
TL;DR: In this paper, autologous stem CElls were used to reverse ventric dySfunction of infarcted segments at 1 year post-MI, and the results showed that scar shrinkage correlated with an increase in viability and with improvement in regional function.
Journal ArticleDOI
Engraftment, Differentiation, and Functional Benefits of Autologous Cardiosphere-Derived Cells in Porcine Ischemic Cardiomyopathy
Peter V. Johnston,Tetsuo Sasano,Kevin J. Mills,Robert Evers,Shuo Tsan Lee,Rachel Ruckdeschel Smith,Albert C. Lardo,Shenghan Lai,Charles Steenbergen,Gary Gerstenblith,Richard A. Lange,Eduardo Marbán +11 more
TL;DR: Intracoronary delivery of CDCs in a preclinical model of postinfarct left ventricular dysfunction results in formation of new cardiac tissue, reduces relative infarct size, attenuates adverse remodeling, and improves hemodynamics.