A
Alessandro Giacomello
Researcher at Sapienza University of Rome
Publications - 76
Citations - 4854
Alessandro Giacomello is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Stem cell & Hypoxanthine. The author has an hindex of 22, co-authored 75 publications receiving 4524 citations.
Papers
More filters
Journal ArticleDOI
Isolation and Expansion of Adult Cardiac Stem Cells From Human and Murine Heart
Elisa Messina,Luciana De Angelis,Giacomo Frati,Stefania Morrone,Stefano Chimenti,Fabio Fiordaliso,Monica Salio,Massimo Battaglia,Michael V.G. Latronico,M. Coletta,E. Vivarelli,Luigi Frati,Giulio Cossu,Alessandro Giacomello +13 more
TL;DR: The isolation of undifferentiated cells that grow as self-adherent clusters (that are termed “cardiospheres”) from subcultures of postnatal atrial or ventricular human biopsy specimens and from murine hearts are described.
Journal ArticleDOI
Regenerative Potential of Cardiosphere-Derived Cells Expanded From Percutaneous Endomyocardial Biopsy Specimens
Rachel R Smith,Lucio Barile,Lucio Barile,Hee Cheol Cho,Michelle K. Leppo,Joshua M. Hare,Elisa Messina,Elisa Messina,Alessandro Giacomello,M. Roselle Abraham,Eduardo Marbán +10 more
TL;DR: Cardiogenic CDCs are cardiogenic in vitro; they promote cardiac regeneration and improve heart function in a mouse infarct model, which provides motivation for further development for therapeutic applications in patients.
Journal ArticleDOI
Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice
Isotta Chimenti,Rachel Ruckdeschel Smith,Tao-Sheng Li,Gary Gerstenblith,Elisa Messina,Alessandro Giacomello,Eduardo Marbán +6 more
TL;DR: Together with their spontaneous commitment to cardiac and angiogenic differentiation, transplanted CDCs serve as “role models,” recruiting endogenous regeneration and improving tissue resistance to ischemic stress.
Journal ArticleDOI
Epicardial application of cardiac progenitor cells in a 3D-printed gelatin/hyaluronic acid patch preserves cardiac function after myocardial infarction.
Roberto Gaetani,Roberto Gaetani,Roberto Gaetani,Dries A. M. Feyen,Vera Verhage,Rolf Slaats,Elisa Messina,Karen L. Christman,Alessandro Giacomello,Pieter A. Doevendans,Joost P.G. Sluijter +10 more
TL;DR: An effective and translational approach is developed to enhance hCMPC delivery and action in the heart by evaluating the therapeutic potential of a 3D-printed patch composed of human cardiac-derived progenitor cells in a hyaluronic acid/gelatin (HA/gel) based matrix.
Journal ArticleDOI
Cardiac stem cells: Isolation, expansion and experimental use for myocardial regeneration
Lucio Barile,Isotta Chimenti,Roberto Gaetani,Elvira Forte,Fabio Miraldi,Giacomo Frati,Elisa Messina,Alessandro Giacomello +7 more
TL;DR: Cardiac stem cells represent a logical source to exploit in cardiac regeneration therapy because, unlike other adult stem cells, they are likely to be intrinsically programmed to generate cardiac tissue in vitro and to increase cardiac tissue viability in vitro.