Radmila Kancheva

TL;DR: The conjugated 3betaOH5S (the key products of the FZFA), estrogens, some polar conjugates of progesterone 5alpha/beta-reduced metabolites and some steroid 7alpha/ beta- and 16alpha-hydroxy-metabolites showed strong positive correlations with the GA.

TL;DR: Brain synthesis may provide minimal level of neurosteroids, which are indispensable for the CNS functions, but substantial part of the steroid metabolites may be also synthesized in the CNS from the steroid precursors or directly transported through BBB from the periphery.

TL;DR: Evaluated data indicates increasing progesterone synthesis and its concurrently increasing catabolism with approaching parturition, and confirms declining production of pregnancy sustaining 5β-pregnane steroids providing uterine quiescence in late pregnancy, increased sulfation of further neuroinhibiting and pregnancy sustaining steroids.

TL;DR: The role of steroid hormones (androgens, estrogens, gestagens, mineralocorticoids, glucocortics, as well as secosteroid vitamin D) in the impairment of glucose tolerance in pregnancy and in the pathogenesis of gestational diabetes mellitus is focused on.

TL;DR: The hypothesis of the role of isopregnanolone in the onset of parturition of pregnanolone was weakened, as the results indicated changing ratios between 3 alpha- and 3beta-PI and between 5alpha- and 5 beta-PI throughout pregnancy.