Rafael Alfonso-Cristancho

TL;DR: This study evaluated the cost-effectiveness of common bariatric surgical procedures in the US from a healthcare system perspective and developed a two-part model using a deterministic approach for the first 5-year period post-surgery and separate empirical forecasts for the natural history of BMI, costs and outcomes in the remaining years.

TL;DR: It was shown that in patients with severe asthma, mepolizumab seems to be at least as effective as omalizumabs and that the tolerability profiles of the two treatments did not meaningfully differentiate.

TL;DR: The MFP approach provides a robust alternative to categorization or conventional linear-quadratic models for BMI, which limit the number of curve shapes, and is potentially useful in estimating the relationship between the full spectrum of BMI values and other health outcomes, or costs.

TL;DR: The CERTAIN's inaugural cohort study may serve as a useful model for conducting PCOR and creating a learning health care network and the patient centeredness of this cohort study is focused on.

TL;DR: This work has described the components of the CERTAIN infrastructure, the elements of a pilot project evaluating treatments of claudication, and the opportunities and challenges of developing and implementing a "real world" learning system.