R
Rafael C. Dutra
Researcher at Universidade Federal de Santa Catarina
Publications - 77
Citations - 3243
Rafael C. Dutra is an academic researcher from Universidade Federal de Santa Catarina. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Receptor. The author has an hindex of 31, co-authored 70 publications receiving 2538 citations. Previous affiliations of Rafael C. Dutra include Universidade do Extremo Sul Catarinense & Universidade Federal de Juiz de Fora.
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Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives.
TL;DR: Pre-clinical and clinical studies with some selected Brazilian medicinal plants in different areas of interest, conducted by research groups in Brazil and abroad are focused on, highlighting the Brazilian market of herbal products and the efforts of Brazilian scientists to develop new phytomedicines.
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Omega-3 Fatty Acid-Derived Mediators 17(R)-Hydroxy Docosahexaenoic Acid, Aspirin-Triggered Resolvin D1 and Resolvin D2 Prevent Experimental Colitis in Mice
Allisson Freire Bento,Rafaela Franco Claudino,Rafael C. Dutra,Rodrigo Marcon,João B. Calixto +4 more
TL;DR: The results suggest that these lipid mediators possess a greater efficacy when compared with other currently used IBD therapies, such as monoclonal anti-TNF, and have the potential to be used for treating IBD.
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β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway.
Allisson Freire Bento,Rodrigo Marcon,Rafael C. Dutra,Rafaela Franco Claudino,Maíra Cola,Daniela F. P. Leite,João B. Calixto +6 more
TL;DR: It is demonstrated that the anti-inflammatory effect of BCP involves CB2 and the PPARγ pathway and suggest BCP as a possible therapy for the treatment of inflammatory bowel disease.
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Antioxidant and cytotoxic activities of Centella asiatica (L) Urb.
TL;DR: A positive correlation was established between the level of flavonoids, antioxidant and antitumor activities and a promising activity against mouse melanoma, human breast cancer and rat glioma cell lines.
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The precursor of resolvin D series and aspirin‐triggered resolvin D1 display anti‐hyperalgesic properties in adjuvant‐induced arthritis in rats
Juliana F. Lima-Garcia,Rafael C. Dutra,Kabs da Silva,Emerson Marcelo Motta,Maria M. Campos,João B. Calixto +5 more
TL;DR: The possible anti‐hyperalgesic effects of two lipids, aspirin‐triggered resolvin D1 (AT‐RvD1) and its precursor, 17(R)‐hydroxy‐4Z,7Z,10Z,13Z,15E,17R,19Z‐docosahexaenoic acid (17 (R)HDoHE) are investigated.