Showing papers by "Raghunathan Rengaswamy published in 1997"
TL;DR: The model prediction matches well with the experimental data of simultaneous growth of E. coli K12 on a mixture of glucose and organic acids like lactate, pyruvate, and acetate and the model predictions are well in agreement with earlier published experimental data.
Abstract: A comprehensive model is developed based on an optimal strategy describing varied microbial growth phenomenon involving sequential and simultaneous utilization of substrate. The model mimics the complex regulatory process of a cell which results in diverse growth process with the help of simple multi-variable constrained optimization, which aims at maximizing the specific cell growth. The metabolic processes of a cell are represented by simple flux balance equations. The different growth phenomenon exhibited by a microorganism are attributed to different levels of control present inside the cell. Provision is made in the model for these controls, in the form of constraints in the optimization formulation. The model prediction matches well with the experimental data of simultaneous growth of E. coli K12 on a mixture of glucose and organic acids like lactate, pyruvate, and acetate. Moreover, the model predictions are well in agreement with earlier published experimental data for the growth of E. coli K12 on other organic acids like fumarate, alpha-ketoglutarate, and succinate. (c) 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 56: 635-644, 1997.
39 citations
TL;DR: A model developed for microbial growth using simple representation of complex cell structure as an optimization function which regulates the interplay of cellular machinery has the ability to prove analytically that the growth on the mixture of two sugars will be diauxic if one of the substrates has a very low K s value and a high μ m value.
29 citations