R
Raja Jayaram
Researcher at University of Oxford
Publications - 25
Citations - 886
Raja Jayaram is an academic researcher from University of Oxford. The author has contributed to research in topics: Perioperative & Medicine. The author has an hindex of 9, co-authored 18 publications receiving 730 citations. Previous affiliations of Raja Jayaram include John Radcliffe Hospital & Clinical Trial Service Unit.
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Journal ArticleDOI
Perioperative Rosuvastatin in Cardiac Surgery.
Zhe Zheng,Raja Jayaram,Lixin Jiang,Jonathan Emberson,Yan Zhao,Qi Li,Juan Du,Silvia Guarguagli,Michael Hill,Zhengming Chen,Rory Collins,Barbara Casadei +11 more
TL;DR: Perioperative statin therapy did not prevent postoperative atrial fibrillation or perioperative myocardial damage in patients undergoing elective cardiac surgery.
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Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation Implications for the Antiarrhythmic Effect of Statins
Svetlana Reilly,Raja Jayaram,Keshav Nahar,Charalambos Antoniades,Sander Verheule,Keith M. Channon,Nicholas J. Alp,Ulrich Schotten,Barbara Casadei +8 more
TL;DR: Upregulation of atrial NADPH oxidases is an early but transient event in the natural history of AF and changes in the sources of reactive oxygen species with atrial remodeling may explain why statins are effective in the primary prevention of AF but not in its management.
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Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment.
Charalambos Antoniades,Michael Demosthenous,Svetlana Reilly,Marios Margaritis,Mei-Hua Zhang,Alexios S. Antonopoulos,Kyriakoula Marinou,Keshav Nahar,Raja Jayaram,Dimitris Tousoulis,Constantinos Bakogiannis,Rana Sayeed,Costas Triantafyllou,Nikolaos Koumallos,Costas Psarros,Antigoni Miliou,Christodoulos Stefanadis,Keith M. Channon,Barbara Casadei +18 more
TL;DR: It is suggested that inhibition of myocardial NADPH oxidases may contribute to the beneficial effect of statins in patients undergoing cardiac surgery.
Journal ArticleDOI
Quality of Reporting in Randomized Trials Published in High-Quality Surgical Journals
TL;DR: Assessment of the quality of reporting of trial methodology and adverse events in a sample of general surgical RCTs published in high-quality surgical journals using the criteria specified in the Consolidated Standards of Reporting Trials (CONSORT) statements found poor reporting of generic methodologic, adverse-event-related, and specific nonpharmacologic criteria.
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Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase
Svetlana Reilly,Xing Liu,Ricardo Carnicer,Alice Recalde,Anna Muszkiewicz,Raja Jayaram,Maria Cristina Carena,Rohan S. Wijesurendra,Matilde Stefanini,Nicoletta C. Surdo,Oliver Lomas,Chandana Ratnatunga,Rana Sayeed,George Krasopoulos,Timothy Rajakumar,Alfonso Bueno-Orovio,Sander Verheule,Tudor A. Fulga,Blanca Rodriguez,Ulrich Schotten,Barbara Casadei +20 more
TL;DR: Atrial-specific up-regulation of microRNA-31 (miR-31) in goat and human AF depletes neuronal nitric oxide synthase (nNOS) by accelerating mRNA decay and alters nNOS subcellular localization by repressing dystrophin translation, and may represent a potential therapeutic target in AF.