R
Rajiv Kumar
Researcher at Institute of Medical Sciences, Banaras Hindu University
Publications - 45
Citations - 2222
Rajiv Kumar is an academic researcher from Institute of Medical Sciences, Banaras Hindu University. The author has contributed to research in topics: Visceral leishmaniasis & Immune system. The author has an hindex of 24, co-authored 45 publications receiving 1836 citations. Previous affiliations of Rajiv Kumar include Banaras Hindu University & Netaji Subhas Institute of Technology.
Papers
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Journal ArticleDOI
Immunobiology of visceral leishmaniasis
Rajiv Kumar,Susanne Nylén +1 more
TL;DR: In this review, immunological events described in human and experimental VL and how these can affect the outcome of infection are discussed.
Journal ArticleDOI
IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis.
Shalini Gautam,Rajiv Kumar,Radheshyam Maurya,Radheshyam Maurya,Susanne Nylén,Susanne Nylén,Nasim Akhtar Ansari,Madhukar Rai,Shyam Sundar,David B. Sacks +9 more
TL;DR: Findings provide direct support for targeting IL-10 as an approach to therapy in human VL and promote parasite killing in 73% and complete clearance in 30%, while 18% had more parasites and 9% did not change.
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Vaccines to prevent leishmaniasis
TL;DR: The understanding of host immunity following Leishmania infection is reviewed and recent advances in the development of vaccines to prevent leishmaniasis are discussed, highlighting a new promising approach that targets the parasite hemoglobin receptor.
Journal ArticleDOI
IL-27 and IL-21 are Associated with T Cell IL-10 Responses in Human Visceral Leishmaniasis
Nasim Akhtar Ansari,Rajiv Kumar,Shalini Gautam,Susanne Nylén,Om Prakash Singh,Shyam Sundar,David B. Sacks +6 more
TL;DR: Proinflammatory cytokines acting on macrophages in the VL spleen have the potential to upregulate IL-27, which in turn can induce IL-21 to expand IL-10–producing T cells as a mechanism of feedback control.
Journal ArticleDOI
CD8 T Cell Exhaustion in Human Visceral Leishmaniasis
Shalini Gautam,Rajiv Kumar,Neetu Singh,Abhishek Kumar Singh,Madhukar Rai,David B. Sacks,Shyam Sundar,Susanne Nylén +7 more
TL;DR: CD8 T cells are driven to anergy/exhaustion in human VL, which affect their ability to contribute to protective immune responses, andGene and surface marker expression suggest that splenic CD8 cell predominantly display an anergic phenotype, whereas CD8-PBMC have features of both anergic cells and CTLs.