S
Shalini Gautam
Researcher at Texas Biomedical Research Institute
Publications - 31
Citations - 1933
Shalini Gautam is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Visceral leishmaniasis & Interferon gamma. The author has an hindex of 17, co-authored 31 publications receiving 1361 citations. Previous affiliations of Shalini Gautam include Ohio State University & Institute of Medical Sciences, Banaras Hindu University.
Papers
More filters
Journal ArticleDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Fatai S. Oladunni,Jun-Gyu Park,Paula A. Pino,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Xavier Alvarez,Deepak Kaushal,Luis D. Giavedoni,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.
Journal ArticleDOI
Serial Quantitative PCR Assay for Detection, Species Discrimination, and Quantification of Leishmania spp. in Human Samples
Jason L. Weirather,Selma M. B. Jeronimo,Shalini Gautam,Shyam Sundar,Mitchell Kang,Melissa A. Kurtz,Rashidul Haque,Albert Schriefer,Sinésio Talhari,Edgar M. Carvalho,John E. Donelson,Mary E. Wilson +11 more
TL;DR: Serial qPCR is useful for leishmania detection and species determination and for absolute quantification when compared to a standard curve from the same Leishmania species.
Journal ArticleDOI
IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis.
Shalini Gautam,Rajiv Kumar,Radheshyam Maurya,Radheshyam Maurya,Susanne Nylén,Susanne Nylén,Nasim Akhtar Ansari,Madhukar Rai,Shyam Sundar,David B. Sacks +9 more
TL;DR: Findings provide direct support for targeting IL-10 as an approach to therapy in human VL and promote parasite killing in 73% and complete clearance in 30%, while 18% had more parasites and 9% did not change.
Posted ContentDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice
Fatai S. Oladunni,Jun-Gyu Park,Paula Pino Tamayo,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Deepak Kaushal,Luis D. Giavedoni,Xavier Alvarez,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.
Journal ArticleDOI
Immunological perspectives of leishmaniasis
Susanne Nylén,Shalini Gautam +1 more
TL;DR: An updated overview of immunological response considered to be of importance in protection, susceptibility, disease progression and cure of leishmaniasis, with a special emphasis on human diseases is given.