R
Ralf A. Hilger
Publications - 5
Citations - 216
Ralf A. Hilger is an academic researcher. The author has contributed to research in topics: Downregulation and upregulation & Receptor. The author has an hindex of 5, co-authored 5 publications receiving 174 citations.
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Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma
Claudia Friesen,Inis Hormann,Mareike Roscher,Iduna Fichtner,Andreas Alt,Ralf A. Hilger,Klaus-Michael Debatin,Erich Miltner +7 more
TL;DR: The findings suggest that opioid receptor activation triggering downregulation of cAMP is a promising strategy to inhibit tumor growth and to improve the effectiveness of anti-cancer drugs in treatment of glioblastoma and in killing gliOBlastoma stem cells.
Journal ArticleDOI
Cell death sensitization of leukemia cells by opioid receptor activation
Claudia Friesen,Mareike Roscher,Inis Hormann,Iduna Fichtner,Andreas Alt,Ralf A. Hilger,Klaus-Michael Debatin,Erich Miltner +7 more
TL;DR: It is demonstrated that opioid receptor activation via triggering the downregulation of cAMP induces apoptosis, activates caspases and sensitizes leukemia cells for doxorubicin treatment, which seems to be a promising strategy to improve anticancer therapies.
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In Vitro and In Vivo Investigations into the Carbene Silver Acetate Anticancer Drug Candidate SBC1
Iduna Fichtner,Jindrich Cinatl,Martin Michaelis,Lara C. Sanders,Ralf A. Hilger,Breandán N. Kennedy,Alison L. Reynolds,Frauke Hackenberg,Grainne Lally,Susan J. Quinn,Ian McRae,Matthias Tacke +11 more
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Improved Treatment of MT-3 Breast Cancer and Brain Metastases in a Mouse Xenograft by LRP-Targeted Oxaliplatin Liposomes.
TL;DR: The newly developed OxP liposomes significantly improved the treatment of subcutaneously and intracerebrally growing breast cancer, but the targeted angiopep-equipped liposome showed no superior effect in vivo.