R
Ramana V. Gutala
Researcher at Oregon Health & Science University
Publications - 3
Citations - 430
Ramana V. Gutala is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Gene expression & BACE1-AS. The author has an hindex of 3, co-authored 3 publications receiving 410 citations.
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Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease
P. Hemachandra Reddy,Shannon K. McWeeney,Byung Park,Maria Manczak,Ramana V. Gutala,Dara Partovi,Youngsin Jung,Vincent Yau,Robert P. Searles,Motomi Mori,Joseph F. Quinn +10 more
TL;DR: The results suggest that mitochondrial energy metabolism is impaired by the expression of mutant APP and/or Abeta, and that the up-regulation of mitochondrial genes is a compensatory response.
Journal ArticleDOI
The use of real-time PCR analysis in a gene expression study of Alzheimer's disease post-mortem brains.
TL;DR: Real-time PCR analysis results indicate that mRNA expression can be detected in all brain specimens for beta-actin, 18S rRNA, GAPDH, and also synaptophysin, a known marker for AD, and suggest that synaptophysical activity is down-regulated in AD brain specimens compared to control brain specimens.
Journal ArticleDOI
P1-227 Gene expression profiles of transcripts in amyloid precursor protein transgenic mice Up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease
P. Hemachandra Reddy,Shannon K. McWeeney,Byung Park,Maria Manczak,Ramana V. Gutala,Youngsin Jung,Vincent Yau,Robert P. Searles,Motomi Mori,Quinn Joseph +9 more