R
Ramasamy Thangavel
Researcher at University of Missouri
Publications - 35
Citations - 1660
Ramasamy Thangavel is an academic researcher from University of Missouri. The author has contributed to research in topics: Neuroinflammation & Glia maturation factor. The author has an hindex of 17, co-authored 35 publications receiving 1037 citations. Previous affiliations of Ramasamy Thangavel include United States Department of Veterans Affairs & University of Iowa Hospitals and Clinics.
Papers
More filters
Neuroinflammation Induces Neurodegeneration.
Duraisamy Kempuraj,Ramasamy Thangavel,Prashant Natteru,Govindhasamy Pushpavathi Selvakumar,Daniyal Saeed,Haris Zahoor,Smita Zaheer,Shankar S. Iyer,Asgar Zaheer +8 more
TL;DR: Though inflammation is crucial in the onset and the progression of neurodegenerative diseases, anti-inflammatory drugs do not provide significant therapeutic effects in these patients till date, as the disease pathogenesis is not yet clearly understood.
Journal ArticleDOI
Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration
Duraisamy Kempuraj,Duraisamy Kempuraj,Ramasamy Thangavel,Ramasamy Thangavel,Govindhasamy Pushpavathi Selvakumar,Govindhasamy Pushpavathi Selvakumar,Smita Zaheer,Mohammad Ejaz Ahmed,Sudhanshu P. Raikwar,Sudhanshu P. Raikwar,Haris Zahoor,Daniyal Saeed,Prashant Natteru,Shankar S. Iyer,Shankar S. Iyer,Asgar Zaheer,Asgar Zaheer +16 more
TL;DR: It is suggested that mast cell-associated inflammatory mediators from systemic inflammation and brain could augment neuroinflammation and neurodegeneration in the brain.
Journal ArticleDOI
COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation.
Duraisamy Kempuraj,Duraisamy Kempuraj,Govindhasamy Pushpavathi Selvakumar,Govindhasamy Pushpavathi Selvakumar,Mohammad Ejaz Ahmed,Mohammad Ejaz Ahmed,Sudhanshu P. Raikwar,Sudhanshu P. Raikwar,Ramasamy Thangavel,Ramasamy Thangavel,Asher Khan,Smita Zaheer,Shankar S. Iyer,Shankar S. Iyer,Casey Burton,Donald James,Asgar Zaheer,Asgar Zaheer +17 more
TL;DR: COVID-19 can induce mast cell activation, psychological stress, cytokine storm, and neuro inflammation, and in conclusion, SARS-CoV-2 infection can cause psychological stress and neuroinflammation.
Journal ArticleDOI
Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma.
Duraisamy Kempuraj,Duraisamy Kempuraj,Ramasamy Thangavel,Ramasamy Thangavel,Deepak D. Kempuraj,Mohammad Ejaz Ahmed,Mohammad Ejaz Ahmed,Govindhasamy Pushpavathi Selvakumar,Govindhasamy Pushpavathi Selvakumar,Sudhanshu P. Raikwar,Sudhanshu P. Raikwar,Smita Zaheer,Shankar S. Iyer,Shankar S. Iyer,Raghav Govindarajan,Premkumar Nattanmai Chandrasekaran,Asgar Zaheer,Asgar Zaheer +17 more
TL;DR: Luteolin can improve cognitive decline and enhance neuroprotection in neurodegenerative diseases, TBI, and stroke, and recent reports suggest that luteolin suppresses systemic and neuroinflammatory responses in Coronavirus disease 2019.
Journal ArticleDOI
Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer's Disease Brain.
Mohammad Ejaz Ahmed,Shankar S. Iyer,Shankar S. Iyer,Ramasamy Thangavel,Ramasamy Thangavel,Duraisamy Kempuraj,Duraisamy Kempuraj,Govindhasamy Pushpavathi Selvakumar,Govindhasamy Pushpavathi Selvakumar,Sudhanshu P. Raikwar,Sudhanshu P. Raikwar,Smita Zaheer,Asgar Zaheer,Asgar Zaheer +13 more
TL;DR: The results indicate that in AD, the neuroinflammation promoted by the NLRP3 inflammasome may be amplified and regulated by GMF, which further impairs clearance of protein aggregates mediated by the auto-phagosomal pathway.