中枢神経系疾患の治療は正常細胞（ニューロン）の機能維持を目的とするが，脳血管障害のように機能障害の原因が細胞の死滅に基づくことは多い．一方，脳腫瘍の治療においては薬物療法や放射線療法といった腫瘍細胞の死滅を目標とするものが大きな位置を占める．いずれの場合にも，細胞死の機序を理解することは各種病態や治療法の理解のうえで重要である．現在のところ最も研究の進んでいる細胞死の型はアポトーシスである．そのなかで重要な位置を占めるミトコンドリアにおける反応および抗アポトーシス因子について概要を紹介する．

Neuroscience 細胞死：最近の知見

An introduction to heat transfer

On the vibrations of the imperfect sandwich higher-order disk with a lactic core using generalize differential quadrature method

This is a fundamental study on the nonlinear vibrations considering large amplitude in multi-sized hybrid Nano-composites (MHC) disk (MHCD) relying on nonlinear elastic media and located in an environment with gradually changed temperature feature. Carbon fibers (CF) or carbon nanotubes (CNTs) in the macro or nano sizes respectively are responsible for reinforcing the matrix. For prediction of the efficiency of the properties MHCD's modified Halpin-Tsai theory has been presented. The strain-displacement relation in multi-sized laminated disk's nonlinear dynamics through applying Von Karman nonlinear shell-theory and using third-order-shear-deformation-theory (TSDT) is determined. The energy methods called Hamilton's principle is applied for deriving the motion equations along with Boundary Conditions (BCs), which has ultimately been solved using the perturbation approach (PA) and generalized differential quadrature method (GDQM). At the final stage, the outcomes illustrate that patterns of FG, fibers' various directions, the WCNT and VF factors, top surface's applied temperature and temperature gradient have considerable impact on the MHCD's nonlinear dynamics. Another important consequence is that, the influences of the θ, WCNT and VF amounts on the disk's nonlinear vibrations may be taken into account at the larger amounts of the high deflection element and the negative axial load's impact on the structure's nonlinear dynamics is more extreme. A more general conclusion of this study is that for designing the MHCD should be more attention to the nonlinearity parameter.

Extremely large oscillation and nonlinear frequency of a multi-scale hybrid disk resting on nonlinear elastic foundation

Experimental investigation of mechanical properties, formability and forming limit diagrams for tailor-welded blanks produced by friction stir welding

Forming limit diagram is often used as a criterion to predict necking initiation in sheet metal forming processes. In this study, the forming limit diagram was obtained through the inclusion of the...

Forming limit diagrams by including the M–K model in finite element simulation considering the effect of bending:

In the present study, a special heat treatment cycle (step quenching) was used to produce a dual-phase (DP) microstructure in low carbon steel. By producing this DP microstructure, the mechanical properties of the investigated steel such as yield stress, tensile strength, and Vickers hardness were increased 14, 55, and 38%, respectively. In order to investigate the effect of heat treatment on formability of the steel, Nakazima forming test was applied and subsequently finite element base modeling was used to predict the outcome on forming limit diagrams. The results show that the DP microstructure also has a positive effect on formability. The results of finite element simulations are in a good agreement with those obtained by the experimental test.

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Ramin Hashemi

Papers

Experimental investigation of mechanical properties, formability and forming limit diagrams for tailor-welded blanks produced by friction stir welding

Forming limit diagrams by including the M–K model in finite element simulation considering the effect of bending:

Enhancing the Mechanical Properties and Formability of Low Carbon Steel with Dual-Phase Microstructures

Forming limit diagrams with the existence of through-thickness normal stress

A methodology for prediction of forming limit stress diagrams considering the strain path effect