R
Ranganatha R. Somasagara
Researcher at Indian Institute of Science
Publications - 4
Citations - 489
Ranganatha R. Somasagara is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Cytotoxicity & Cancer. The author has an hindex of 3, co-authored 3 publications receiving 376 citations.
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Journal ArticleDOI
Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis.
Shikha Srivastava,Ranganatha R. Somasagara,Mahesh Hegde,Mayilaadumveettil Nishana,Satish Kumar Tadi,Mrinal Srivastava,Bibha Choudhary,Sathees C. Raghavan +7 more
TL;DR: It is found that quercetin interacts with DNA directly, and could be one of the mechanisms for inducing apoptosis in both, cancer cell lines and tumor tissues by activating the intrinsic pathway.
Journal ArticleDOI
Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice.
Ranganatha R. Somasagara,Mahesh Hegde,Kishore K. Chiruvella,Anjaneyulu Musini,Bibha Choudhary,Sathees C. Raghavan +5 more
TL;DR: It is revealed that strawberry fruits possess both cancer preventive and therapeutic values and the mechanism by which it is achieved is discussed.
Journal ArticleDOI
Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse.
Elizabeth Thomas,Vidya Gopalakrishnan,Ranganatha R. Somasagara,Bibha Choudhary,Sathees C. Raghavan +4 more
TL;DR: In this paper, the authors used Vernonia condensata (VCE) extract to explore its anticancer activity using various approaches and showed that extract prepared from VCE exhibits cytotoxic properties against various cancer cells in a dose-and time-dependent manner.
Book ChapterDOI
Zebrafish Xenograft Model to Study Human Cancer.
TL;DR: The zebrafish model is a good alternative in vivo model to mammals for robust testing of drug candidates for cancer therapy and suitable for small molecule drug screening in high-throughput setting.