S
Shikha Srivastava
Researcher at Indian Institute of Science
Publications - 3
Citations - 390
Shikha Srivastava is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Apoptosis & Homologous recombination. The author has an hindex of 3, co-authored 3 publications receiving 291 citations.
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Journal ArticleDOI
Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis.
Shikha Srivastava,Ranganatha R. Somasagara,Mahesh Hegde,Mayilaadumveettil Nishana,Satish Kumar Tadi,Mrinal Srivastava,Bibha Choudhary,Sathees C. Raghavan +7 more
TL;DR: It is found that quercetin interacts with DNA directly, and could be one of the mechanisms for inducing apoptosis in both, cancer cell lines and tumor tissues by activating the intrinsic pathway.
Journal ArticleDOI
Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2-BAK interaction.
Supriya V. Vartak,Divyaanka Iyer,T.R. Santhoshkumar,Sheetal Sharma,Archita Mishra,Gunaseelan Goldsmith,Mrinal Srivastava,Shikha Srivastava,Subhas S. Karki,Avadhesha Surolia,Bibha Choudhary,Sathees C. Raghavan +11 more
TL;DR: A unique mechanism of action of a BCL2 inhibitor, Disarib, is reported, by specifically targeting the interaction of B CL2‐BAK, while sparing that of other proapoptotic binding partners.
Journal ArticleDOI
DNA double-strand break repair in Penaeus monodon is predominantly dependent on homologous recombination.
Shikha Srivastava,Sumedha Dahal,Sharanya J. Naidu,Deepika Anand,Vidya Gopalakrishnan,Rajendran Kooloth Valappil,Sathees C. Raghavan +6 more
TL;DR: It is shown that HR-mediated DSB repair is the predominant mode of repair in P. monodon, and evidence is detected for an alternative mode of NHEJ that uses microhomology, termed as microHomology-mediated end joining (MMEJ).