R
Ranjala Ratnayake
Researcher at University of Florida
Publications - 58
Citations - 1412
Ranjala Ratnayake is an academic researcher from University of Florida. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 19, co-authored 52 publications receiving 1112 citations. Previous affiliations of Ranjala Ratnayake include National Institutes of Health & University of Queensland.
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Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.
TL;DR: Bioassay-guided fractionation yielded two new guaiane sesquiterpenes, englerins A and B that showed 1000-fold selectivity against six of eight renal cancer cell lines with GI(50) values ranging from 1-87 nM.
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Citromycetins and bilains A-C: new aromatic polyketides and diketopiperazines from Australian marine-derived and terrestrial Penicillium spp.
TL;DR: The structures for the Penicillium metabolites 1- 18 were assigned by a combination of detailed spectroscopic analysis, including correlation with relevant literature data, chemical derivatization, degradation, and biosynthetic considerations.
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Kibdelones: Novel anticancer polyketides from a rare Australian actinomycete
TL;DR: Kibdelones exhibit potent and selective cytotoxicity against a panel of human tumor cell lines and display significant antibacterial and nematocidal activity.
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Englerin A Stimulates PKCθ to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality
Carole Sourbier,Bradley T. Scroggins,Ranjala Ratnayake,Thomas Prince,Sunmin Lee,Min-Jung Lee,Peter Literati Nagy,Young H. Lee,Jane B. Trepel,John A. Beutler,W. Marston Linehan,Len Neckers +11 more
TL;DR: By promoting glucose addiction, while simultaneously starving cells of glucose, EA proves to be synthetically lethal to highly glycolytic tumors.
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C3 and 2D C3 Marfey's Methods for Amino Acid Analysis in Natural Products.
Soumini Vijayasarathy,Pritesh Prasad,Leith J. Fremlin,Ranjala Ratnayake,Angela A. Salim,Zeinab G. Khalil,Robert J. Capon +6 more
TL;DR: The improved resolution and sensitivity of the C3 Marfey's method is validated, including an ability to resolve all Ile isomers, against an array of amino acids commonly encountered in natural products and by comparison to an existing Marfney's method.