S
Sunmin Lee
Researcher at National Institutes of Health
Publications - 99
Citations - 5799
Sunmin Lee is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 33, co-authored 81 publications receiving 4783 citations. Previous affiliations of Sunmin Lee include University of Maryland, Baltimore.
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Journal ArticleDOI
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
Jennifer S. Isaacs,Yun Jin Jung,David R. Mole,Sunmin Lee,Carlos Torres-Cabala,Yuen-Li Chung,Maria J. Merino,Jane B. Trepel,Berton Zbar,Jorge R. Toro,Peter J. Ratcliffe,W. Marston Linehan,Len Neckers +12 more
TL;DR: In this article, a novel fumarate-dependent pathway for regulating HPH activity and HIF protein levels was proposed, which coincides with FH inhibition and upregulation of HIF upregulation.
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IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.
TL;DR: It is demonstrated that IL‐1β up‐regulates functional HIF‐1α protein through a classical inflammatory signaling pathway involving NFkB and COX‐2, culminating in up‐regulation of VEGF, a potent angiogenic factor required for tumor growth and metastasis.
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Curcumin is an Inhibitor of p300 Histone Acetylatransferase
Len Neckers,Jane B. Trepel,Sunmin Lee,Eun-Joo Chung,Min-Jung Lee,Yunjin Jung,Monica G. Marcu +6 more
TL;DR: Curcumin is demonstrated to be a selective HAT inhibitor and to effectively block histone hyperacetylation in both PC3-M prostate cancer cells and peripheral blood lymphocytes induced by the histone deacetylase inhibitor MS-275.
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Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.
Mercedes Garayoa,Alfredo Martínez,Sunmin Lee,Ruben Pio,Won G. An,Len Neckers,Jane B. Trepel,Luis M. Montuenga,Heather E. Ryan,Randall S. Johnson,Max Gassmann,Frank Cuttitta +11 more
TL;DR: This paper showed that the expression of AM mRNA in a variety of human tumor cell lines is highly induced in a time-dependent manner by reduced oxygen tension (1% O2) or exposure to hypoxia mimetics such as desferrioxamine mesylate (DFX) or CoCl2.
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Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis
Soichiro Yoshida,Shinji Tsutsumi,Guillaume Muhlebach,Carole Sourbier,Min-Jung Lee,Sunmin Lee,Evangelia Vartholomaiou,Manabu Tatokoro,Kristin Beebe,Naoto Miyajima,Robert P. Mohney,Yang Chen,Hisashi Hasumi,Wanping Xu,Hiroshi Fukushima,Ken Nakamura,Fumitaka Koga,Kazunori Kihara,Jane B. Trepel,Didier Picard,Leonard M. Neckers +20 more
TL;DR: The authors showed that TRAP1-deficiency promotes an increase in mitochondrial respiration and fatty acid oxidation, and in cellular accumulation of tricarboxylic acid cycle intermediates, ATP and reactive oxygen species.