R
Raphael Nudelman
Researcher at Weizmann Institute of Science
Publications - 7
Citations - 397
Raphael Nudelman is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Substance P & Neurokinin A. The author has an hindex of 6, co-authored 7 publications receiving 375 citations.
Papers
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Journal ArticleDOI
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
Oren M. Becker,Dhanoa Dale S,Yael Marantz,Chen Dongli,Sharon Shacham,Srinivasa Rao Cheruku,Alexander Heifetz,Pradyumna Mohanty,Merav Fichman,Anurag Sharadendu,Raphael Nudelman,Michael Kauffman,Silvia Noiman +12 more
TL;DR: This paper reports the discovery of a novel, potent, and selective amidosulfonamide nonazapirone 5-HT1A agonist for the treatment of anxiety and depression, which is now in Phase III clinical trials for generalized anxiety disorder (GAD).
Journal ArticleDOI
Modular Fluorescent-Labeled Siderophore Analogues
TL;DR: All tested compounds, regardless of their probe size, polarity, or the linker binding them to the siderophore analogue, promote growth of Pseudomonas putida with the same efficacy as the nonlabeled analogues 1, with the added benefit of signaling microbial activity by fluorescence emission.
Journal ArticleDOI
Iron Uptake in Ustilago maydis: Tracking the Iron Path
Orly Ardon,Raphael Nudelman,Catherine Caris,Jacqueline Libman,Abraham Shanzer,Yona Chen,Yitzhak Hadar +6 more
TL;DR: The use of fluorescent biomimetic siderophores as tools to directly track and discriminate between different pathways of iron uptake in cells is introduced.
Patent
Substituted aminopyrimidine compounds as neurokinin antagonists
Dhanoa Dale S,Oren Becker,Silvia Noiman,Venkitasamy Kesavan,Anurag Sharadendu,Pradyumna Mohanty,Chen Dongli,Srinivasa Rao Cheruku,Alexander Heifetz,Ori Kalid,Yael Marantz,Raphael Nudelman,Sharon Sbacham,Shay Bar-Haim +13 more
TL;DR: In this paper, the tachykinin family of receptors comprising the neurokinins substance P (SP), neurokinin A, and neuro-kinin B and related neuropeptides that are widely distributed in the peripheral and central nervous system.
Patent
Substituted aminopyrimidines as neurokinin antagonists
Dhanoa Dale S,Oren Becker,Chen Dongli,Srinivasa Rao Cheruku,Alexander Heifetz,Ori Kalid,Venkitasamy Kesavan,Yael Marantz,Pradyumna Mohanty,Silvia Noiman,Raphael Nudelman,Sharon Sbacham,Anurag Sharadendu,Shay Bar-Haim +13 more
TL;DR: In this paper, the tachykinin family of receptors comprising the neurokinins substance P (SP), neurokinin A, and neuro-kinin B and related neuropeptides that are widely distributed in the peripheral and central nervous system.