Ratih Ratih

TL;DR: In this review, microscale thermophoresis technology (MST) is presented as an analytical technique for characterizing biomolecular interactions and is found to be a powerful technique in quantitation of binding events based on the movement of molecules in microscopic temperature gradient.

TL;DR: Mobility shift-affinity capillary electrophoresis was employed for enantioseparation and simultaneous binding constant determination and the low measurement uncertainty of this approach was demonstrated by the close agreement of the association constant of the enantiopure S-(-)-form

TL;DR: In this review, the aspects related to similarity testing of biosimilars to the original biological products are discussed involving manufacturing challenges to ensure the quality, safety, and efficacy of these products to the patient health.

TL;DR: Chondroitin sulfate A was covalently immobilized onto a monolithic silica epoxy column involving a Schiff base formation in the presence of ethylenediamine as a spacer and evaluated in terms of its selectivity in enantioseparation.

TL;DR: Two capillary electrophoresis–based ligand binding assays were applied to determine binding parameters of human serum albumin toward small drugs under similar experimental conditions to estimate and compare both the assays in terms of their primary measure's precision and the reproducibility of the derived binding parameters.