Raveen Rathnasinghe

TL;DR: The data presented here validates the choice of antigens that contain the PP mutation and suggests that deletion of the polybasic cleavage site could lead to a further optimized design of vaccine design.

TL;DR: In this article, the authors demonstrated increased susceptibility of lipid-enveloped respiratory pathogens of importance such as SARS-CoV-2 (causative agent of COVID-19) and influenza A virus to 405nm, visible light in the absence of exogenous photosensitizers thereby indicating a potential alternativeporphyrin-independent mechanism of visible light mediated viral inactivation.

TL;DR: It was demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection resulted in subclinical disease in rhesus macaques with mild pneumonia and clinical disease in Syrian hamsters with severe pneumonia, and macaques may be appropriate for mechanistic studies of mild asymptomatic CO VID-19 pneumonia and COVID-19-associated encephalitis.

TL;DR: In this article, an intranasal, rationally designed adjuvant integrating a nanoemulsion (NE) that activates TLRs and NLRP3 with an RNA agonist of RIG-I (IVT DI) was developed.

TL;DR: These data support the reuse of N95 particle-filtrate apparatus upon irradiation with UVC and supports use of UVC-based decontamination of SARS-CoV-2 virus during the COVID19 pandemic.