R
Raveen Rathnasinghe
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 42
Citations - 2394
Raveen Rathnasinghe is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Virus. The author has an hindex of 12, co-authored 30 publications receiving 1037 citations. Previous affiliations of Raveen Rathnasinghe include Mount Sinai Health System.
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Journal ArticleDOI
Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants
J. Andrew Duty,Thomas Kraus,Heyue Zhou,Yanliang Zhang,Namir Shaabani,Soner Yildiz,Na Du,Ajay K. Singh,Lisa Miorin,Donghui Li,K. Stegman,Sabrina I Ophir,Xia Cao,Kristina Atanasoff,Reyna Kv Lim,Ignacio Mena,Nicole M. Bouvier,Shreyas Kowdle,Juan Manuel Carreño,Laura Rivero-Nava,A. Raskin,Elena Moreno,Sachi Johnson,Raveen Rathnasinghe,Chin I. Pai,Thomas Kehrer,Elizabeth Paz Cabral,Sonia Jangra,Laura Healy,Gagandeep Singh,Prajakta Warang,Viviana Simon,Emilia Mia Sordillo,Harm van Bakel,Yonghong Liu,Weina Sun,Lisa Kerwin,John R. Teijaro,Michael Schotsaert,Florian Krammer,Damien Bresson,Adolfo García-Sastre,Yanwen Fu,Benhur Lee,Colin J. Powers,Thomas Moran,Henry Ji,Domenico Tortorella,Robert D. Allen +48 more
TL;DR: In this article , a broad spectrum neutralizing antibody, STI-9167, has been developed and used to produce cGMP drug product intended for intravenous or intranasal use in human clinical trials.
Posted ContentDOI
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Thomas Kehrer,Anastasija Cupic,Chengjin Ye,Soner Yildiz,Mehdi Bouhhadou,Nicholas A. Crossland,Erika A. Barrall,Phillip Cohen,Anna Tseng,Tolga Cagatay,Raveen Rathnasinghe,Daniel Flores,Sonia Jangra,Fahmida Alam,na Jaime García Mena,Sadaf Aslam,Anjali Saqi,Arturo Marin,Magdalena Rutkowska,Manisha Ummadi,Giuseppe Pisanelli,R. Blake Richardson,Ethan C. Veit,Jacqueline M. Fabius,Margaret Soucheray,Benjamin J. Polacco,Matthew J. Evans,Danielle L. Swaney,Ana S. Gonzalez-Reiche,Emilia Mia Sordillo,Harm van Bakel,Viviana Simon,Lorena Zuliani-Alvarez,Beatriz M. A. Fontoura,Brad R. Rosenberg,Nevan J. Krogan,Luis Martinez-Sobrido,Adolfo García-Sastre,Lisa Miorin +38 more
TL;DR: In this paper , the role of ORF6 during infection using recombinant SARS-CoV-2 viruses carrying either a deletion or a well characterized M58R loss-of-function mutation in ORFs was further assessed.
Journal ArticleDOI
Scalable, effective, and rapid decontamination of SARS-CoV-2 contaminated N95 respirators using germicidal ultraviolet C (UVC) irradiation device.
Raveen Rathnasinghe,Robert F. Karlicek,Michael Schotsaert,Mattheos A. G. Koffas,Brigitte L. Arduini,Sonia Jangra,Bowen Wang,Jason L Davis,Mohammed Alnaggar,Anthony Costa,Richard L. Vincent,Adolfo García-Sastre,Deepak Vashishth,Priti Balchandani +13 more
TL;DR: In this paper, a scalable UVC device to deliver tailored UVC dose for rapid decontamination of SARS-CoV-2 during the COVID-19 pandemic was developed.
Posted ContentDOI
Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants
J. Andrew Duty,Thomas Kraus,Heyue Zhou,Yanliang Zhang,Namir Shaabani,Soner Yildiz,Na Du,Ajay K. Singh,Lisa Miorin,Donghui Li,K. Stegman,Sabrina I Ophir,Xia Cao,Kristina Atanasoff,Reyna Kv Lim,Shreyas Kowdle,Juan Manuel Carreño,Laura Rivero-Nava,A. Raskin,Elena Moreno,Sachi Johnson,Raveen Rathnasinghe,Chin I. Pai,Thomas Kehrer,Elizabeth Paz Cabral,Sonia Jangra,Laura Healy,Gagandeep Singh,Prajakta Warang,Viviana Simon,Mia Emilia Sordillo,Harm van Bakel,Yonghong Liu,Weina Sun,Lisa Kerwin,Peter Palese,John R. Teijaro,Michael Schotsaert,Florian Krammer,Damien Bresson,Adolfo García-Sastre,Yanwen Fu,Benhur Lee,Colin J. Powers,Thomas M. Moran,Henry Ji,Domenico Tortorella,Robert D. Allen +47 more
TL;DR: Following a campaign of antibody discovery based on the vaccination of Harbour H2L2 mice with defined SARS-CoV-2 spike domains, the activity of a large collection of Spike-binding antibodies is characterized and a lead neutralizing human IgG1 LALA antibody, STI-9167, is identified.
Posted ContentDOI
A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine
Sonia Jangra,Jeffrey J. Landers,Raveen Rathnasinghe,Jessica J. O’Konek,Katarzyna W. Janczak,Marilia Cascalho,Andrew A Kennedy,Andrew W. Tai,James R. Baker,Michael Schotsaert,Pamela T. Wong +10 more
TL;DR: In this paper, an intranasal, rationally designed adjuvant integrating a nanoemulsion (NE) that activates TLRs and NLRP3 with an RNA agonist of RIG-I (IVT DI) was developed.