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Ravi S. Kamath
Researcher at University of Cambridge
Publications - 15
Citations - 15083
Ravi S. Kamath is an academic researcher from University of Cambridge. The author has contributed to research in topics: RNA interference & Caenorhabditis elegans. The author has an hindex of 14, co-authored 15 publications receiving 14201 citations.
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Journal ArticleDOI
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Ravi S. Kamath,Andrew G. Fraser,Andrew G. Fraser,Yan Dong,Gino B. Poulin,Richard Durbin,Monica Gotta,Alexander Kanapin,Nathalie Le Bot,Sergio Moreno,Sergio Moreno,Marc Sohrmann,David P. Welchman,Peder Zipperlen,Julie Ahringer +14 more
TL;DR: It is found that genes of similar functions are clustered in distinct, multi-megabase regions of individual chromosomes; genes in these regions tend to share transcriptional profiles.
Journal ArticleDOI
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Coleen T. Murphy,Steven A. McCarroll,Cornelia I. Bargmann,Andrew G. Fraser,Ravi S. Kamath,Julie Ahringer,Hao Li,Cynthia Kenyon +7 more
TL;DR: The findings suggest that the insulin/IGF-I pathway ultimately exerts its effect on lifespan by upregulating a wide variety of genes, including cellular stress-response, antimicrobial and metabolic genes, and by downregulating specific life-shortening genes.
Journal ArticleDOI
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
Andrew G. Fraser,Ravi S. Kamath,Peder Zipperlen,Maruxa Martinez-Campos,Marc Sohrmann,Julie Ahringer +5 more
TL;DR: A reusable library of bacterial clones is constructed that will permit unlimited RNAi screens in the future and should help develop a more complete view of the relationships between the genome, gene function and the environment.
Journal ArticleDOI
Genome-wide RNAi screening in Caenorhabditis elegans.
Ravi S. Kamath,Julie Ahringer +1 more
TL;DR: A library of bacterial strains corresponding to roughly 86% of the estimated 19,000 predicted genes in C. elegans is constructed, and this library is used to perform genome-wide analyses of gene function.
Journal ArticleDOI
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
TL;DR: In this article, an optimized feeding method was presented that results in phenotypes at least as strong as those produced by direct injection of dsRNA for embryonic lethal genes, and stronger for genes with post-embryonic phenotypes.