http://www.heartrhythmjournal.com/article/S1547527122021853/pdf

Postural orthostatic tachycardia syndrome as a sequela of COVID-19

In this observational cross-sectional study, we investigated predictors of orthostatic intolerance (OI) in adults reporting long COVID symptoms. Participants underwent a 3-min active stand (AS) with Finapres® NOVA, followed by a 10-min unmedicated 70° head-up tilt test. Eighty-five participants were included (mean age 46 years, range 25–78; 74% women), of which 56 (66%) reported OI during AS (OIAS). OIAS seemed associated with female sex, more fatigue and depressive symptoms, and greater inability to perform activities of daily living (ADL), as well as a higher heart rate (HR) at the lowest systolic blood pressure (SBP) point before the first minute post-stand (mean HRnadir: 88 vs. 75 bpm, P = 0.004). In a regression model also including age, sex, fatigue, depression, ADL inability, and peak HR after the nadir SBP, HRnadir was the only OIAS predictor (OR = 1.09, 95% CI: 1.01–1.18, P = 0.027). Twenty-two (26%) participants had initial (iOH) and 5 (6%) classical (cOHAS) orthostatic hypotension, but neither correlated with OIAS. Seventy-one participants proceeded to tilt, of which 28 (39%) had OI during tilt (OItilt). Of the 53 who had a 10-min tilt, 7 (13%) had an HR increase >30 bpm without cOHtilt (2 to HR > 120 bpm), but six did not report OItilt. In conclusion, OIAS was associated with a higher initial HR on AS, which after 1 min equalised with the non-OIAS group. Despite these initial orthostatic HR differences, POTS was infrequent (2%). ClinicalTrials.gov Identifier: NCT05027724 (retrospectively registered on August 30, 2021).

/pdf/orthostatic-intolerance-in-adults-reporting-long-covid-1iaoqcjx.pdf

Orthostatic Intolerance in Adults Reporting Long COVID Symptoms Was Not Associated With Postural Orthostatic Tachycardia Syndrome

/pdf/orthostatic-intolerance-in-long-haul-covid-after-sars-cov-2-2aeh7k6n.pdf

Orthostatic Intolerance in Long-Haul COVID after SARS-CoV-2: A Case-Control Comparison with Post-EBV and Insidious-Onset Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

https://www.mdpi.com/2227-9032/10/10/2105/pdf?version=1666324639

Long-Haul COVID Patients: Prevalence of POTS Are Reduced but Cerebral Blood Flow Abnormalities Remain Abnormal with Longer Disease Duration

Lidocaine/sotalol

A 32-year-old woman with a history of symptomatic supraventricular tachycardia, inappropriate sinus tachycardia, and hyperadrenergic POTS was treated with ivabradine and metoprolol. She then presented with bradycardia and Mobitz II second-degree AV block on event monitoring six weeks after COVID-19 infection. Her post-viral workup revealed normalization of catecholamine levels and significant symptomatic improvement in heart rate. To the authors' knowledge, this is the first reported case of improvement in POTS after COVID-19 infection. As our understanding of COVID-19 continues to improve, it will be vital to better understand the impact of COVID-19 dysautonomia on cardiac patients.

/pdf/clinical-and-laboratory-improvement-in-hyperadrenergic-3vefo20dai.pdf

Clinical and Laboratory Improvement in Hyperadrenergic Postural Orthostatic Tachycardia Syndrome (POTS) after COVID-19 Infection.

Apple watch detected ventricular tachycardia in a pregnant patient

http://www.jscai.org/article/S2772930323005215/pdf

Mitral Regurgitation in Female Patients: Sex Differences and Disparities

Despite awareness by health-care providers that diet impacts cardiovascular health, there remains a knowledge gap in how to evaluate the impact in an objective way. This chapter discusses the use of novel and clinically relevant biomarkers to quantitatively and objectively assess cardiac risk for different dietary patterns. Data will be presented on how plant-based eating patterns that limit red meat consumption (e.g. Mediterranean diet) promote cardiovascular health and improve cardiovascular biomarkers such as LDL and HDL, Hs-CRP, Trimethylamine N-oxide (TMAO), and vitamin D.

Rebecca A Ocher

Papers

Clinical and Laboratory Improvement in Hyperadrenergic Postural Orthostatic Tachycardia Syndrome (POTS) after COVID-19 Infection.

Apple watch detected ventricular tachycardia in a pregnant patient

Mitral Regurgitation in Female Patients: Sex Differences and Disparities

Impact of Nutrition on Biomarkers of Cardiovascular Health