Rebecca L. Fouts

TL;DR: In failed human heart, PKC-beta1 and -beta2 expression and contribution to total PKC activity are significantly increased, which may signal a role for Ca2+-sensitive PKC isoforms in cardiac mechanisms involved in heart failure.

TL;DR: The correlation between decreased MAPKAPK-2 phosphorylation and loss of active p38MAPK in failing human myocytes suggests that decreases in the activation of p38 MAPK alpha, the predominant cardiac isoform, occur prior to end-stage heart failure.

TL;DR: In the human heartPKC- alpha, PKC- epsilon, and Cx-43 appear to form a closely associated complex, with PKC activity significantly above endogenous levels in the co-immunoprecipitated CX-43 complexes.

TL;DR: The type II collagen-induced mouse arthritis model may not be highly suitable for detection of the traditional nonsteroidal anti-inflammatory class of drugs or the anti-rheumatic drugs, although the possibility remains that some new and novel immunosuppressive agents may be detected with this model.

TL;DR: In this article, female MRL lpr / lpr mice have been dosed po daily for 7 months with the selective estrogen receptor modulator (SERM) LY139478 or 17α-ethinylestradiol (EE2, 1 mg/kg) and compared to vehicle control animals.