R
Rebekka Geiger
Publications - 3
Citations - 1248
Rebekka Geiger is an academic researcher. The author has contributed to research in topics: Interleukin 33 & Interleukin 21. The author has an hindex of 2, co-authored 2 publications receiving 1169 citations.
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Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
TL;DR: The differentiation of T cells producing only IL-22 was efficiently induced in naive T cells by plasmacytoid dendritic cells in an IL-6- and tumor necrosis factor–dependent way and delineate a previously unknown subset of human CD4+ effector T cells dedicated to skin pathophysiology.
Journal ArticleDOI
Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells
TL;DR: Libraries of polyclonally expanded naive T cells were used to determine frequency and antigen dose–response of human naive CD4+ T cells specific for a variety of antigens and to isolate antigen-specific T cell clones.
Posted ContentDOI
Myeloid mechano-metabolic programming restricts anti-tumor immunity
Kevin M. Tharp,Kelly Kersten,Ori Maller,Greg A. Timblin,Connor Stashko,Fernando Pablo Canale,Mary-Kate Hayward,I. Berestjuk,J. ten Hoeve-Scott,Bushra Samad,Alastair Ironside,Rebekka Geiger,Alexis J. Combes,Valerie M. Weaver +13 more
TL;DR: It is demonstrated that tumor infiltrating myeloid cells respond to the stiffened fibrotic tumor microenvironment (TME) by initiating a TGF-beta (TGFβ)-directed, collagen biosynthesis program that creates an inhospitable metabolic milieu for CD8+ T cells.