R
Reinhold G. Erben
Researcher at University of Veterinary Medicine Vienna
Publications - 186
Citations - 9405
Reinhold G. Erben is an academic researcher from University of Veterinary Medicine Vienna. The author has contributed to research in topics: Bone remodeling & Fibroblast growth factor 23. The author has an hindex of 48, co-authored 181 publications receiving 8237 citations. Previous affiliations of Reinhold G. Erben include Harvard University & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice.
Despina Sitara,Mohammed S. Razzaque,Martina Hesse,Subbiah Yoganathan,Takashi Taguchi,Reinhold G. Erben,Harald Jüppner,Beate Lanske +7 more
TL;DR: FGF-23 is upstream of the phosphate regulating gene with homologies to endopeptidases on the X chromosome (Phex) and that the increased plasma Fgf-23 levels in Hyp mice (and in XLH patients) may be at least partially responsible for the phosphate imbalance in this disorder.
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Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor.
TL;DR: The findings clearly establish a molecular role of the VDR in pancreatic insulin synthesis and secretion in vivo and exclude possible influences of hypocalcemia on pancreatic endocrine function.
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Embedding of Bone Samples in Methylmethacrylate: An Improved Method Suitable for Bone Histomorphometry, Histochemistry, and Immunohistochemistry
TL;DR: The modified MMA embedding process, using commercially available methacrylates can be used without purification, and the histologic quality of bone sections is comparable to that of conventionally MMA-embedded bone specimens.
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FGF23 regulates renal sodium handling and blood pressure
Olena Andrukhova,Svetlana Slavic,Alina Smorodchenko,Ute Zeitz,Victoria Shalhoub,Beate Lanske,Elena E. Pohl,Reinhold G. Erben +7 more
TL;DR: It is shown that FGF23 directly regulates the membrane abundance of the Na+:Cl− co‐transporter NCC in distal renal tubules by a signaling mechanism involving the FGF receptor/αKlotho complex, extracellular signal‐regulated kinase 1/2 (ERK1/2), serum/glucocorticoid‐regulatedkinase 1 (SGK1), and with‐no lysine kinase‐4 (WNK4
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Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.
Reinhold G. Erben,Desi W. Soegiarto,Karin Weber,Ute Zeitz,Michèle Lieberherr,Robert Gniadecki,Gabriele Möller,Jerzy Adamski,Rudi Balling +8 more
TL;DR: It is shown that gene-targeted mutant mice express a VDR with an intact hormone binding domain, but lacking the first zinc finger necessary for DNA binding, supporting the conclusion that the classical VDR mediates the nongenomic actions of 1,25-(OH)(2)D(3).