Remy Luthringer

TL;DR: The results showed clearly that there was a first-night effect in normal subjects, similar to that reported in previously published data, characterized by a longer rapid eye movement (REM) sleep latency (p < 0.05), increased wakefulness, and total sleep time and a decreased sleep efficiency.

TL;DR: Bearing in mind the composition and the size of the test sample, the automated sleep staging system achieved a satisfactory performance level and may be considered a useful alternative to visual sleep stage scoring for large-scale investigations of human sleep.

TL;DR: A close temporal and quantitative relationship between GH secretion and delta wave activity is demonstrated, which may be evidence of common stimulatory mechanisms.

TL;DR: These early data in healthy subjects provide encouragement to consider development of AZD3480 as a novel agent for the treatment of cognitive decline in the elderly, including age-associated memory impairment and/or dementia of the Alzheimer’s type.

TL;DR: In this paper, the effects of prolonged-release melatonin 2 mg (PRM) on sleep and subsequent daytime psychomotor performance in patients aged > or =55 years with primary insomnia, as defined by the fourth revision of the Diagnostic and Statistical Manual of Mental Disorders of the American Psychiatric Association Patients (N = 40) were treated nightly single-blind with placebo (2 weeks), randomized double-blind to PRM or placebo (3 weeks) followed by withdrawal period (1 week).