Rémy P. Barbe

TL;DR: Benefits of antidepressants appear to be much greater than risks from suicidal ideation/suicide attempt across indications, although comparison of benefit to risk varies as a function of indication, age, chronicity, and study conditions.

TL;DR: In this paper, the authors examined characteristics and predictors of response to placebo in all available reports of short-term randomized controlled trials of antidepressants for pediatric major depressive disorder, and found that the single best predictor of patients taking placebo who responded to treatment was the number of study sites.

TL;DR: Longitudinal studies are needed to elucidate the temporal relationship between decision-making processes and suicidal behavior and to help frame potential targets for early identification and preventive interventions to reduce youth suicide and suicidalbehavior.

TL;DR: There appears to be a sex difference for some clinical features, particularly hopelessness, among depressed suicidal children and adolescents, and whether hopelessness is a sex-specific characteristic of depressed suicidalChildren and adolescents requires further study.

TL;DR: Emergent suicidality is a common occurrence in psychosocial treatment of adolescent depression, with rates similar to those reported recently in antidepressant trials, and to evaluate accurately the role of treatment, it is important to assess self-reported suicideality at intake and to balance treatment groups on this key predictor.