Renato Scacchi

TL;DR: This finding confirms the important role for APOE in AD occurrence and APOC1 seems to be an interesting marker because, though in strict linkage disequilibrium with APOE, it seems to play an independent role in AD risk.

TL;DR: A new polyacrylamide gel isoelectric focusing (PAGIEF) technique has been developed that allows rapid and reliable identification of Apolipoprotein E (APOE) phenotypes directly from plasma or serum without any prior treatment.

TL;DR: The present data suggest that the involvement of ESR1 polymorphisms in AD onset is mediated by the regulation of apoE expression, and ESR 1 polymorphisms are also associated with a faster cognitive decline in the women AD patients.

TL;DR: No genotype or allele of the polymorphisms examined here seemed to be associated with vascular dementia or with Alzheimer’s disease, total cholesterol and LDL cholesterol levels were lower in Alzheimer”s disease patients than in vascular dementia patients and in elderly controls, and the dementia patients with APOB EcoRI R+R– genotype had higher totalolesterol and cholesterol levels than R-R+ homozygotes.

TL;DR: Though indicating a significant association with AD onset, the results are far from definitive since contrast with the ones reported by other authors in a previous case–control study, and call for further investigations.