E. Mantuano

TL;DR: No genotype or allele of the polymorphisms examined here seemed to be associated with vascular dementia or with Alzheimer’s disease, total cholesterol and LDL cholesterol levels were lower in Alzheimer”s disease patients than in vascular dementia patients and in elderly controls, and the dementia patients with APOB EcoRI R+R– genotype had higher totalolesterol and cholesterol levels than R-R+ homozygotes.

TL;DR: The data indicate that in AD patients aged less than 81 years, epsilon 4 is clearly associated with AD and that it can be considered a risk factor for AD chiefly before this age.

TL;DR: In the Italian women studied, the DNA polymorphisms studied do not seem to be important risk factors for CAD occurrence; apoE quantitation could be another useful parameter to identify subjects at risk of CAD; and APOB X‐and APOE*2 are the alleles that most influence the interindividual plasma lipid variation among CAD female patients.

TL;DR: Three DNA polymorphisms (XbaI, EcoRI, and Ins/Del) of the apolipoprotein B (APOB) gene and the CfoI polymorphism of the APOE gene were investigated in a sample of 96 Cayapa Indians from Ecuador, and the frequencies of the X+, R+, and Del alleles were found to be higher than and to differ significantly from those reported for East Asians.

TL;DR: The effect of three thiol reagents on erythrocyte adenosine deaminase activity has been studied and p-chloromercuribenzoate treatment results in a reduction of enzymatic activity which is statistically significant only for ADA 1, but not ADA 2-1 phenotype haemolysates.