R
Rhonda Geoffrey
Researcher at Medical College of Wisconsin
Publications - 14
Citations - 796
Rhonda Geoffrey is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Biobreeding rat & Type 1 diabetes. The author has an hindex of 10, co-authored 14 publications receiving 729 citations. Previous affiliations of Rhonda Geoffrey include Children's Hospital of Wisconsin.
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Journal ArticleDOI
An autoinflammatory disease due to homozygous deletion of the IL1RN locus.
Sreelatha T. Reddy,Shuang Jia,Rhonda Geoffrey,Rachel Lorier,Mariko Suchi,Ulrich Broeckel,Martin J. Hessner,James W. Verbsky +7 more
TL;DR: A patient with an autoinflammatory disease in which the main clinical features are pustular rash, marked osteopenia, lytic bone lesions, respiratory insufficiency, and thrombosis is described, which contains a 175-kb homozygous deletion at chromosome 2q13, which encompasses several interleukin-1 family members.
Journal ArticleDOI
Identification of a Molecular Signature in Human Type 1 Diabetes Mellitus Using Serum and Functional Genomics
Xujing Wang,Xujing Wang,Shuang Jia,Rhonda Geoffrey,Ramin Alemzadeh,Soumitra Ghosh,Soumitra Ghosh,Martin J. Hessner,Martin J. Hessner +8 more
TL;DR: This study supports prior investigations of serum that reflect disease processes associated with progression to T1DM and indicates that identification of unique inflammatory mediators may improve disease prediction beyond current islet autoantibodies.
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Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat.
Rhonda Geoffrey,Shuang Jia,Anne E. Kwitek,Jeffrey Woodliff,Soumitra Ghosh,Åke Lernmark,Xujing Wang,Martin J. Hessner +7 more
TL;DR: It is found that PLN mast cells are more abundant in DRlyp/lyp compared with related BB DR+/+ rats and eotaxin expression begins before 40 days of life and is localized specifically to β cells, consistent with a growing body of evidence in human and animal models.
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Molecular signatures differentiate immune states in type 1 diabetic families.
Yi-Guang Chen,Susanne M. Cabrera,Shuang Jia,Mary L. Kaldunski,Joanna Kramer,Sami Cheong,Rhonda Geoffrey,Mark F. Roethle,Jeffrey Woodliff,Carla J. Greenbaum,Xujing Wang,Martin J. Hessner +11 more
TL;DR: Cross-sectional and longitudinal analyses of healthy autoantibody-negative (AA−) high HLA−risk siblings (HRS) (DR3 and/or DR4) and AA− low H LA− risk siblings (LRS) revealed a mechanism underlying the decline in T1D susceptibility with age.
Journal ArticleDOI
Involvement of Eotaxin, Eosinophils, and Pancreatic Predisposition in Development of Type 1 Diabetes Mellitus in the BioBreeding Rat
Martin J. Hessner,Xujing Wang,Lisa Meyer,Rhonda Geoffrey,Shuang Jia,Jessica M. Fuller,Åke Lernmark,Soumitra Ghosh +7 more
TL;DR: Gen expression profiling was conducted on pancreatic lymph nodes of DRlyp/lyp, DR+/+, and Wistar-Furth rats to better understand immune processes during development of T1DM and suggest that the lymphopenia due to the Ian5/(lyp) mutation may result in a deregulation of cells involved in insulitis and β cell destruction.