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Carla J. Greenbaum
Researcher at Benaroya Research Institute
Publications - 247
Citations - 17563
Carla J. Greenbaum is an academic researcher from Benaroya Research Institute. The author has contributed to research in topics: Type 1 diabetes & Diabetes mellitus. The author has an hindex of 65, co-authored 229 publications receiving 14769 citations. Previous affiliations of Carla J. Greenbaum include Veterans Health Administration & Virginia Mason Medical Center.
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Journal ArticleDOI
Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function
Mark D. Pescovitz,Carla J. Greenbaum,Heidi Krause-Steinrauf,Dorothy J. Becker,Stephen E. Gitelman,Robin Goland,Peter A. Gottlieb,Jennifer B. Marks,Paula McGee,Antoinette Moran,Philip Raskin,Henry Rodriguez,Desmond A. Schatz,Diane K. Wherrett,Darrell M. Wilson,John M. Lachin,Jay S. Skyler +16 more
TL;DR: The finding that B lymphocytes contribute to the pathogenesis of type 1 diabetes may open a new pathway for exploration in the treatment of patients with this condition.
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Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association.
Richard A. Insel,Jessica L. Dunne,Mark A. Atkinson,Jane L. Chiang,Dana Dabelea,Peter A. Gottlieb,Carla J. Greenbaum,Kevan C. Herold,Jeffrey P. Krischer,Åke Lernmark,Robert E. Ratner,Marian Rewers,Desmond A. Schatz,Jay S. Skyler,Jay M. Sosenko,Anette-G. Ziegler +15 more
TL;DR: Adoption of this staging classification provides a standardized taxonomy for type 1 diabetes and will aid the development of therapies and the design of clinical trials to prevent symptomatic disease, promote precision medicine, and provide a framework for an optimized benefit/risk ratio.
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Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.
Jay S. Skyler,Jeffrey P. Krischer,Joseph I. Wolfsdorf,Catherine C. Cowie,Jerry P. Palmer,Carla J. Greenbaum,David Cuthbertson,Lisa Rafkin-Mervis,Chase Hp,Leschek E +9 more
TL;DR: It is possible to identify individuals at high risk for type 1 diabetes and to enroll them in a large, multisite, randomized, controlled clinical trial, however, oral insulin did not delay or prevent type 1 Diabetes in nondiabetic relatives at risk for diabetes.
Journal ArticleDOI
Improvement in outcomes of clinical islet transplantation: 1999-2010.
Franca B. Barton,Michael R. Rickels,Rodolfo Alejandro,Bernhard J. Hering,Stephen Wease,Bashoo Naziruddin,Jose Oberholzer,Jon S. Odorico,Marc R. Garfinkel,Marlon F. Levy,François Pattou,Thierry Berney,Antonio Secchi,Shari Messinger,Peter A. Senior,Paola Maffi,Andrew M. Posselt,Peter G. Stock,Dixon B. Kaufman,Xunrong Luo,Fouad Kandeel,Enrico Cagliero,Nicole A. Turgeon,Piotr Witkowski,Ali Naji,Philip J. O'Connell,Carla J. Greenbaum,Yogish C. Kudva,Kenneth L. Brayman,Meredith J. Aull,Christian P. Larsen,Thomas W.H. Kay,Luis A. Fernandez,Marie-Christine Vantyghem,Melena D. Bellin,A. M. James Shapiro +35 more
TL;DR: The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007–2010 compared with those in 1999–2006, with fewer islet infusions and adverse events per recipient.
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Identification of tissue-specific cell death using methylation patterns of circulating DNA.
Roni Lehmann-Werman,Daniel Neiman,Hai Zemmour,Joshua Moss,Judith Magenheim,Adi Vaknin-Dembinsky,Sten Rubertsson,Bengt Nellgård,Kaj Blennow,Henrik Zetterberg,Henrik Zetterberg,Kirsty L. Spalding,Michael J. Haller,Clive Wasserfall,Desmond A. Schatz,Carla J. Greenbaum,Craig Dorrell,Markus Grompe,Aviad Zick,Ayala Hubert,Myriam Maoz,Volker Fendrich,Detlef K. Bartsch,Talia Golan,Shmuel Ben Sasson,Gideon Zamir,Aharon Razin,Howard Cedar,A. M. James Shapiro,Benjamin Glaser,Ruth Shemer,Yuval Dor +31 more
TL;DR: The tissue origins of cfDNA and thus the rate of death of specific cell types can be determined in humans, offering a minimally invasive window for diagnosing and monitoring a broad spectrum of human pathologies as well as providing a better understanding of normal tissue dynamics.