Ever since Edeleano (1887) made the first synthesis of phenyl-substituted aliphatic amines, this type of compound has been an object of research. Stern (1889) initially showed that beta-tetrahydronaphtylamine caused a motoric unrest in rabbits, and Airila (1913) supported this finding in the same species with ephedrine, which later was used to treat narcolepsy by Janota (1931). Alles (1933) demonstrated that beta-phenylisopropylamine sulphate is antagonistic to hypnotics. The introduction of Benzedrine in therapy (Prinzmetal and Bloomberg, 1935) made this group of amines the object of a closer study in humans because of its peculiar effects on the central nervous system. The psychiatric literature of 1936 and 1937 contained several articles on the use of Benzedrine, both in psychotic and non-psychotic persons (Donley, 1937).

Changes in Individual and Social Behavior Induced by Amphetamine and Related Compounds in Monkeys and Man

http://link.springer.com/content/pdf/10.1007/978-1-4615-7734-8_5.pdf

Patient Characteristics as Predictors of Treatment Outcomes for Alcohol and Drug Abusers

Drug use is measured in a number of different ways in drug treatment outcome studies. Different measures of outcome may yield different results, making comparison across studies difficult. The utility, sensitivity, and level of measurement of five categories of measures are reviewed. It is suggested that research focus on examining the properties of existing drug use measures, on developing methods of evaluating timing and sequence in the relapse process, and on standardizing measurement approaches across studies.

Choosing Drug Use Measures for Treatment Outcome Studies. I. The Influence of Measurement Approach on Treatment Results

Psychological Aspects of Heroin and Other Drug Dependence

The many paths to drug dependence.

A Systematic Approach to Drug Abuse Treatment Referral

(1972). The Transition to Amphetamine Abuse. Journal of Psychedelic Drugs: Vol. 5, The Politics of Uppers and Downers, pp. 105-111.

Ricardo Hofer

Papers

A Systematic Approach to Drug Abuse Treatment Referral

The Transition to Amphetamine Abuse