R
Richard A. Logan
Researcher at St. Michael's Hospital
Publications - 4
Citations - 455
Richard A. Logan is an academic researcher from St. Michael's Hospital. The author has contributed to research in topics: Restenosis & Matrix metalloproteinase. The author has an hindex of 2, co-authored 4 publications receiving 450 citations.
Papers
More filters
Journal ArticleDOI
Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis.
Bradley H. Strauss,Robert J. Chisholm,Fred W. Keeley,A I Gotlieb,Richard A. Logan,P W Armstrong +5 more
TL;DR: Significant increases in collagen, elastin, and proteoglycan synthesis, up to 4 to 10 times above control nondamaged contralateral iliac arteries, were noted at 1, 2, and 4 weeks, accompanied by significant increases in synthesis that coincided with the temporal increase in cross-sectional area.
Journal ArticleDOI
In Vivo Collagen Turnover Following Experimental Balloon Angioplasty Injury and the Role of Matrix Metalloproteinases
Bradley H. Strauss,Ranga Robinson,Wayne Batchelor,Robert J. Chisholm,Grama D. Ravi,Madhu K. Natarajan,Richard A. Logan,Shamir R. Mehta,Daniel E. Levy,Alan M. Ezrin,Fred W. Keeley +10 more
TL;DR: The data suggest that degradation of newly synthesized collagen is an important mechanism regulating collagen accumulation and that MMPs have an integral role in collagen turnover after balloon angioplasty.
Journal ArticleDOI
Matrix metalloproteinase inhibition reduces collagen synthesis and content after arterial injury
Shamir R. Mehta,Robert J. Chisholm,Ranga Robinson,Richard A. Logan,Daniel E. Levy,Alan M. Ezrin,Fred W. Keeley,Bradley H. Strauss +7 more
Journal ArticleDOI
903-14 Collagen Turnover After Balloon Angioplasty Injury
Grama D. Ravi,Robert J. Chisholm,Tony F. Cruz,Richard A. Logan,Fred W. Keeley,Bradley H. Strauss +5 more
TL;DR: Both collagen synthesis and degradation are stimulated after BA, particularly at 1 week, which may explain discrepancies between synthesis and accumulation.