R
Richard Bolton Roman
Publications - 7
Citations - 6453
Richard Bolton Roman is an academic researcher. The author has contributed to research in topics: Alkyl & Pharmaceutical formulation. The author has an hindex of 5, co-authored 7 publications receiving 6301 citations.
Papers
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Journal ArticleDOI
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure
Philip L. Felgner,Thomas R. Gadek,Marilyn Holm,Richard Bolton Roman,Hardy W. Chan,Michael Wenz,Jeffrey P. Northrop,Gordon M. Ringold,Mark Danielsen +8 more
TL;DR: Depending upon the cell line, lipofection is from 5- to greater than 100-fold more effective than either the calcium phosphate or the DEAE-dextran transfection technique.
Patent
N[ omega ,( omega -1)-dialkyloxy]- and N-[ omega ,( omega -1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
Deborah A. Eppstein,Philip L. Felgner,Thomas R. Gadek,Gordon Henry Jones,Richard Bolton Roman +4 more
TL;DR: In this article, the same or different compounds of the formula I or an optical isomer thereof are defined, where R1 and R2 are the same and R3, R4 and R5 are different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms and n is a pharmaceutically acceptable anion.
Patent
N-[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N,-tetrasubstituted ammonium lipids and uses therefor
Deborah A. Eppstein,Philip L. Felgner,Thomas R. Gadek,Gordon Henry Jones,Richard Bolton Roman +4 more
TL;DR: In this article, the authors defined an optical isomer for compounds of the formula "STR1## or an optical anion thereof", where R 1 and R 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R 3, R 4 and R 5 are the different or different, and X is a pharmaceutically acceptable anion.
Patent
N-(omega,omega-1-dialkoxy)- and n-(omega,omega-1-dialkenoxy)-alk-1-yl-n,n,n-trisubstituted ammonium surfactants, their preparation and pharmaceutical formulations containing them
TL;DR: In this article, the authors defined an optical isomer for compounds of the formula R' and R' where R' is the same or different and R 2 is an alkyl or alkenyl group of 6 to 22 carbons; R 3, R 4 and R 5 are different and are hydrogen, aryl, aralkyl of 7 to 11 carbons, and X is a pharmaceutically acceptable anion.