Richard Buist

TL;DR: In this paper, the authors compared the results of the collagenase and blood infusion models of intracerebral hemorrhage (ICH) and found that despite similar initial hematoma volumes, collagenase-induced ICH resulted in a greater blood-brain barrier breakdown and more damage to the striatum, substantia nigra, white matter, and cortex.

TL;DR: The combined cortical and striatal ET-1 produced a high success rate and consequently the cerebral blood flow (CBF), the apparent diffusion coefficient (ADC) and T2-weighted magnetic resonance imaging (MRI) changes for this model were examined.

TL;DR: Of the calculated MRI metrics, ƒ was the strongest indicator of myelin content, while longitudinal relaxation rates and diffusivity measurements were the strongest indicators of changes in tissue structure, like previous studies of multiple sclerosis in humans and animal models of demyelination.

TL;DR: The finding that MPs mediate PTx-induced parenchymal infiltration to the chemokine-overexpressing CNS has relevance for the pathogenesis of human diseases involving CNS inflammation, such as multiple sclerosis.

TL;DR: It is concluded that early shunting is superior to late shunting with regard to behavioral dysfunction, and high-resolution MR imaging shows features in hydrocephalic rats similar to those found in Hydrocephalic humans.