Richard Burchmore

TL;DR: There was an unexpected persistence of immunoglobulin G almost until weaning, potentially indicating prolonged trans-intestinal transfer of IgG and among components of innate immune protection were found fucosyllactose and siallylactose that are thought to impede colonisation by pathogens and encourage an appropriate milk-digestive and protective gut microbiome.

TL;DR: The role of TbAT1 in drug uptake and drug resistance in T. brucei is investigated and a reduction in drug sensitivity is presented, since mice infected with tbat1-null trypanosomes could not be cured with 2 mg of melarsoprol/kg of body weight for four consecutive days, whereas mice infectedwith the parental line were all cured by using this protocol.

TL;DR: The influence of environmental pH on membrane transporter function is discussed, with emphasis on the potential role of a transmembrane proton gradient in active, high affinity transport.

TL;DR: Protozoan purine transporter-encoding genes characterised to date have been of the Equilibrative Nucleoside Transporter family conserved in a great variety of eukaryote organisms, but these protozoan transporters have been shown to be sufficiently different from mammalian transporter to mediate selective uptake of therapeutic agents.

TL;DR: Eflornithine resistance is easy to select through loss of a putative amino acid transporter, TbAAT6, and will be easily identified in the field using a simple PCR test, enabling more appropriate chemotherapy to be administered.